Ion channels, including Ca2+, K+, Na+, and Cl- channels, are critical in regulating various physiological processes, such as maintaining cell membrane potential, facilitating signal transduction, influencing hemodynamics, and controlling vasomotor functions. Inherited mutations, pathological changes, or adverse drug-induced side effects can disrupt ion channel activity, leading to abnormal ion transport across cell membranes and playing a role in the development of neurological disorders, including stroke. On the other hand, extensive studies have shown that modulating the function of key ion channels involved in disease can effectively alleviate symptoms, supporting ion channels as promising targets for the treatment of stroke.
Fig. 1 Ion channels and transporters in microglial function in physiology and brain diseases. (Luo, et al., 2021)
As a stroke research service provider, Ace Therapeutics is committed to providing reliable ion channel modulator development services to research institutions and pharmaceutical companies. By leveraging its deep expertise in ion channel biology and medicinal chemistry, Ace Therapeutics offers a full range of services from target identification and validation, to lead optimization and preclinical evaluation.
| Services | Service Details |
|---|---|
| Target identification and validation | Use advanced genomic and proteomic approaches to identify and validate ion channel targets implicated in stroke pathology, such as voltage-dependent calcium channels (VDCCs), sodium channels, potassium channels, and transient receptor potential (TRP) channels. |
| High-throughput screening (HTS) for ion channel modulators | Screen large compound libraries to identify potential ion channel modulators with high selectivity and efficacy using HTS platforms. |
| Electrophysiological analysis | Provide electrophysiological studies to characterize the functional effects of candidate compounds on ion channel activity. |
| Structure-based drug design | Design and optimize ion channel modulators with improved affinity and specificity according to customer needs by combining X-ray crystallography, cryo-electron microscopy, and computational modeling. |
| Preclinical evaluation | Provide comprehensive in vitro and in vivo studies to assess the neuroprotective effects, pharmacokinetics and safety of drug candidates. |
| Calcium channel blockers | Sodium channel blockers | Potassium channel activators |
| KATP channel modulators | Transient receptor potential (TRP) ion channel blockers | Acid-sensing ion channel (ASIC) modulators |
Ace Therapeutics is committed to helping clients develop innovative ion channel modulators that offer neuroprotection, reduce brain damage, and promote functional recovery after stroke. Our goal is to accelerate the development of novel therapeutics for stroke. If you are interested in our services, please contact us for more information.
Ace Therapeutics is a global leading provider of stroke research services. We are committed to accelerating progress in stroke research and drug development.