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- BBB DamageCell Death and ApoptosisNeuroinflammationNeuronal Damage and RepairOxidative StressVascular Mechanisms
- 3D BBB Models
- Organ-on-a-Chip BBB ModelsTranswell Models3D BBB Models Culture Substrate
- 3D HydrogelsCollagensAnmial BBB ModelsCell Lines for BBB Modeling
- Immortalized CellsPrimary CellsStem Cells
Collagens
Collagen is the main component of connective tissue and is abundant in mammals. It is the most widely used extracellular matrix in 3D cell culture to promote cell attachment, growth, differentiation, migration and tissue morphogenesis.
In the 3D BBB model, collagen is used as the main component of the cell culture matrix to provide a support and attachment matrix for cells, thus supporting the simulation study of complex cell interactions and biological processes.
The 3D BBB model is a three-dimensional cell culture model that simulates the blood-brain barrier and is used to study related neurobiology and drug delivery issues. In order to reproduce real physiological conditions, the 3D BBB model uses a collagen matrix to culture brain vascular endothelial cells and other related cells to form a microenvironment with blood-brain barrier function. Collagen plays different roles when creating a three-dimensional blood-brain barrier (BBB) model culture matrix.
- Has good biocompatibility and can promote cell attachment and growth.
- Has a three-dimensional structure and can simulate the characteristics of real tissues.
- Helps form the structure and function of brain vascular endothelial cells and related cells.
It is worth noting that the choice of collagen for the 3D BBB model culture matrix should be based on the specific requirements of the study and the desired matrix functionality. Furthermore, combining different types of collagen or using mixtures of collagen with other ECM components can further enhance the biomimetic properties and functionality of BBB model culture substrates.
Ace Therapeutics produces and supplies different types of collagen to help you construct an ideal, stable 3D BBB model in vitro that meets your research needs.
Cat.# Name Description Price BBM-3C-046 Rat Tail Collagen I, 3 mg/mL Rat Tail Collagen I, 3 mg/mL from Ace Therapeutics is derived from rat tail, which can be prepared as a clear gel to provide a 3D matrix or surface coating on tissue culture plates as a substrate for culturing primary cells such as keratinocytes and hepatocytes.inquiry BBM-3C-047 Rat Tail Collagen Type I, Sterile, Filtered Rat Tail Collagen Type I, Sterile, Filtered, from Ace Therapeutics is a purified collagen derived from the rat tail. The Product can be used as a thin layer on tissue culture surfaces to enhance cell adhesion and proliferation, or as a glue layer to promote the expression of specific cell morphology and function. The product is typically used to culture endothelial cells, stem cells, muscle cells, and a variety of other cells.inquiry BBM-3C-048 Rat Tail Collagen Type I, High Concentration, Sterile, Filtered Rat Tail Collagen Type I, High Concentration, Sterile, Filtered, from Ace Therapeutics is a highly concentration, purified collagen derived from the rat tail. This product is more suitable for 3D cell culture due to the high concentration improves matrix stiffness and support integrity.inquiry BBM-3C-049 Human Collagen Type I Human Collagen Type I from Ace Therapeutics is a purified collagen derived from adult human placenta tissue, and this product can be used as a thin layer on tissue culture surfaces to enhance cell adhesion and valorization.inquiry BBM-3C-050 Bovine Collagen Type I Bovine Collagen Type I from Ace Therapeutics is a purified collagen derived from bovine tissue. The native collagen sequence contained in the preparation is missing or shortened since this product has been treated with pepsin.inquiry BBM-3C-051 Human Collagen Type III Collagen Type III is found in a variety of conjunctival tissues, including human skin, and the cornea. Human Collagen Type III from Ace Therapeutics is a purified collagen derived from adult human placenta tissue, and the product can be used as a coating on tissue culture surfaces to promote cell adhesion and regulate cell behavior.inquiry BBM-3C-052 Human Collagen Type IV Collagen Type IV is a common component of the basement membrane. Human Collagen Type IV from Ace Therapeutics is a purified collagen derived from adult human placenta tissue, and the product can be used to regulate cell growth, differentiation, and tissue formation.inquiry BBM-3C-053 Mouse Collagen Type IV Collagen Type IV is a common component of the basement membrane. Mouse Collagen Type IV from Ace Therapeutics is a purified collagen derived from murine engelbreth-holm-swarm (EHS) tumor, and the product can be used to regulate cell growth, differentiation, and tissue formation.inquiry BBM-3C-054 Human Collagen Type V Collagen Type V is found in the placenta, amniotic membrane, and cornea. Human Collagen Type V from Ace Therapeutics is a purified collagen from adult human placenta tissue. This product can be used as a coating on tissue culture surfaces to study the effects of collagen on cell behavior.inquiry BBM-3C-055 Human Collagen Type VI Collagen Type VI is a multi-domain ECM. Its heterotrimeric chains pack into a microfibrillar network through tetramerization and tail-end linkage. Human Collagen Type VI from Ace Therapeutics is a purified collagen from adult placenta tissue. This product is usually used for coating and can also be added to cell culture fluid.inquiry BBM-3C-056 Porcine Gelatine Porcine Gelatine from Ace Therapeutics is a purified gelatin matrix from porcine tissue. The product can enhance the adsorption of various normal cells and transfected cells.inquiry BBM-3C-057 Collagen Solution, 3.0 mg/mL Collagen Solution, 3.0 mg/mL from Ace Therapeutics is purified from bovine tissue. The solution is used to prepare collagen-coated cell culture surfaces to promote adhesion, growth, morphology, migration, and differentiation of various cell types. This product is suitable for culturing human hematopoietic stem cells.inquiry BBM-3C-058 Rat Tail Tendon Collagen Type I, 5mg/ml Rat Tail Tendon Collagen Type I, 5mg/ml is prepared by the method of Birkedal-Hansen through acetic acid extraction, sodium chloride precipitation, disodium hydrogen phosphate precipitation, and other steps. This product can be used to coat cell culture vessels and culture some cells that are difficult to adhere to in ordinary cell culture vessels. It can also be used to prepare three-dimensional glue to simulate a real growth environment and allow cells to grow in a three-dimensional environment.inquiry BBM-3C-059 Collagens Type I-A Collagens Type I-A is acid-soluble Type-I collagen derived from porcine tendon. This product can quickly form a gel and is suitable for 3D cell culture products. It has high gel strength and transparency and is easy to observe under the microscope.inquiry BBM-3C-060 Collagens Type I-P Collagens Type I-P is pepsin-solubilized Type-I collagen derived from pig tendon. The product has low viscosity, making it easy to handle and form gels.inquiry All of our products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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