Calcium imaging is the gold standard for assessing neuronal activity and investigating neuronal networks due to the robust relationship between neuronal activity and intracellular calcium fluctuations. In stroke, disruption of calcium homeostasis leads to the activation of deleterious pathways, including excitotoxicity, mitochondrial dysfunction, and cell death mechanisms, thereby exacerbating neuronal damage. Monitoring calcium signaling during stroke helps to elucidate the timing and extent of neuronal damage and provides potential targets for therapeutic intervention to mitigate injury and preserve brain function.
Fig. 1 Waves of calcium activity in the ischemic brain. (Liu, et al., 2021)
At Ace Therapeutics, we specialize in providing calcium imaging services to help our clients study neuronal activity in animal models of stroke. Our advanced imaging technology and expertise allows us to measure neuronal activity in specific brain regions at the cellular level, providing valuable insight into investigating the mechanisms of ischemic brain injury and evaluating the efficacy of stroke therapies.
Our calcium imaging services are designed to to help clients address key questions in stroke research, including:
Model Selection
Assist in selecting the appropriate stroke model, calcium indicator (e.g., GCaMP), and imaging modality.
Data Analysis
Provide detailed analysis of calcium signaling dynamics and neuronal activity.
Consultation
Begin with an in-depth discussion to understand your research goals and design a tailored proposal for calcium imaging.
Experimental Execution
Conduct calcium imaging studies in live animals.
At Ace Therapeutics, we are committed to advancing stroke research through in vivo two-photon calcium imaging technologies. Whether you are investigating the mechanisms of neuronal damage, evaluating neuroprotective therapies, or exploring network reorganization after stroke, our team is here to support your research. Contact us today to learn how our calcium imaging services can enhance your stroke research and accelerate the development of stroke therapies.
Ace Therapeutics is a global leading provider of stroke research services. We are committed to accelerating progress in stroke research and drug development.