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- BBB DamageCell Death and ApoptosisNeuroinflammationNeuronal Damage and RepairOxidative StressVascular Mechanisms
- 3D BBB Models
- Organ-on-a-Chip BBB ModelsTranswell Models3D BBB Models Culture Substrate
- 3D HydrogelsCollagensAnmial BBB ModelsCell Lines for BBB Modeling
- Immortalized CellsPrimary CellsStem Cells
Anmial BBB Models
In vivo animal models are critical tools for basic research and drug discovery. Ace Therapeutics continuously optimizes technology and successfully develops animal BBB models to promote progress in the field of neuroscience and accelerate the translation of research results into clinical applications. Here, we provide you with Mdr1a BBB models to advance your research.
Mdr1a BBB Models
The Mdr1a BBB model is an in vivo animal model developed by Ace Therapeutics to study the role of the blood-brain barrier (BBB) and multidrug resistance gene 1 (Mdr1a) in the field of neuroscience.
The BBB is a protective membrane located between the blood and the central nervous system. Its function is to prevent harmful substances from entering the brain tissue while ensuring the delivery of necessary nutrients to the brain tissue. However, the BBB also restricts the entry of many drugs, which directly affects the therapeutic effect of the drugs.
Mdr1a is a gene encoding P-glycoprotein (P-gp). P-gp is one of the main components of the BBB. Its function is to excrete a variety of drugs from the brain tissue through active transport, which leads to multidrug resistance.
You can choose our Mdr1a BBB models to better understand and evaluate the BBB and the impact of Mdr1a on drugs in neuroscience. This model can also help you determine whether drugs can cross the BBB and how to increase their efficiency across the BBB. In addition, the Mdr1a BBB model can also be used to evaluate and develop drugs targeting BBB and multidrug resistance.
Mdr1a BBB model can provide a powerful tool to help you deeply study and discover issues related to BBB and multidrug resistance.
More animal BBB models are under development...
Cat.# Name Description Price BBM-A-015 Mdr1a BBB Models Mdr1a ( BBB Models) from Ace Therapeutics is a transgenic mouse model. The Mdr1a mouse was created by targeting the Abcb1a gene in E14 ES cells. Resultant chimeras were backcrossed to FVB for seven (N7) generations. Carries a disruption of multi-drug resistance genes Abcb1a (ATP-binding cassette, sub-family B (MDR/TAP), member 1A, a.k.a. Mdr1a) encoding p-glycoprotein 3. Mdr1a protein is expressed actively at the blood-brain barriers. Lack the protective function of p-glycoprotein 3 and exhibits a functional deficiency in the blood-brain barrier.inquiry All of our products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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