Animal Modeling of Stroke

The use of appropriate and rationally designed animal models is necessary to correctly predict the relevance of experimental treatments in humans. At Ace Therapeutics, we are committed to developing customized animal models of ischemic stroke and hemorrhagic stroke to enhance the translational capabilities of your drug discovery and development programs.

The Importance of Stroke Animal Models

There are many animal models available to study the various physiological and pathological changes that occur in stroke and also to evaluate the therapeutic effects of various pharmacological interventions. Stroke being a heterogeneous disease with complex pathophysiology, it is not possible to simulate all aspects of human stroke in one animal model. Each model has unique strengths and weaknesses, so they can be selected for specific studies. Mice and rats are the most commonly used experimental animals, but a variety of other animals such as rabbits, gerbils, cats, dogs, pigs, and monkeys have been used for a thorough understanding of disease pathology and treatment.

Fig. 1. Translational step-wise experimental design for stroke neurotherapeutics. (Tajiri et al., 2013)

Custom Animal Models of Stroke

Ace Therapeutics builds stable and proven animal modeling methods of stroke. Our experts have extensive experience in developing stroke animal models and rigorously validating each model. Our stroke models provide a more comprehensive approach to the disease for your preclinical studies.

At Ace Therapeutics, we use animals to help clients with their stroke drug discovery and development programs through contract research services. We ensure that the best-matched stroke animal model is selected for your project. In addition, we offer a range of outcome measures and functional assessment tests to analyze cognitive and behavioral responses after stroke in animal models.

Custom Animal Models of Ischemic Stroke

We provide global cerebral ischemic stroke and focal cerebral ischemic stroke models to meet customer needs. We offer a variety of methods to construct ischemic stroke models, such as endovascular filament, transcranial electrocoagulation, photothrombosis, endothelin-1 occlusion, embolic occlusion. Our model animals are under the strict control of professional scientists to ensure the scientific validity and rigor of the research.

Custom Animal Models of Hemorrhagic Stroke

With stable and reliable technology and professional scientists, we establish autologous blood injection models and bacterial collagenase injection hemorrhagic stroke models to facilitate hemorrhagic stroke research. Through our model portfolio, active partnerships, and customized services, we eliminate the common challenges of acquiring hemorrhagic stroke models.

Advantages of Animal Stroke Models

• Models that most faithfully represent the human stroke state.
• Outcome tests designed specifically for stroke animal models can assess mood, cognition, sensorimotor deficits, and learning and memory function.
• Rigorous postoperative care protocols that maximize survival and increase the extent and duration of deficits.

With multiple validated animal models, choosing Ace Therapeutics as your preclinical stroke CRO will ensure your research is as close as possible. Need more? Contact us about custom model development. We are constantly developing new models and would be happy to develop one for you to study.

1. Tajiri, N., et al. (2013). In vivo animal stroke models: a rationale for rodent and non-human primate models. Translational stroke research, 4, 308-321.