The BBB is a specialized barrier in the brain that regulates the entry of molecules and cells from the bloodstream into the brain. It plays a crucial role in protecting the brain from harmful substances and maintaining its homeostasis.
Traditional 2D cell model of BBB culture is performed on simple, nonporous two-dimensional (2D) surfaces. Despite the method being easy and convenient, can result in certain well-documented artifacts. The 3D BBB model culture substrate refers to the three-dimensional culture system used for culturing and studying the blood-brain barrier (BBB) model in vitro, which aims to mimic the physiological conditions of the brain's microenvironment, allowing researchers to study BBB function and dysfunction in a controlled laboratory setting. It typically consists of a specialized culture substrate that supports the growth and differentiation of brain endothelial cells, which form the main component of the BBB. The substrate is often coated with extracellular matrix proteins like collagen or laminin to provide a suitable surface for cell attachment and growth.
A well-established method for culturing 3D BBB models is to culture cells on structural scaffolds, which are typically composed of biopolymers, such as 3D hydrogels and collagens, arranged to mimic the physiological extracellular matrix (ECM).
Highlighted below are the types of brackets Ace Therapeutics offers for 3D BBB model culture.
Click on the Links to Access Our 3D BBB Model Culture Substrate:
Cat.# | Name | Description | Price |
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BBM-3C-087 | 3D SG-PVA |
3D SG-PVA consists of polyvinyl alcohol functionalized with thiol-reactive groups (SG-PVA), which can be used together with other components PEG-Link or CD-Link to set up cell-compatible hydrogels.
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BBM-3C-088 | 3D F-Dextran |
3D F-Dextran consists of maleimide-functionalized dextran (Mal-Dextran), which can be used together with other components PEG-Link or CD-Link to set up cell-compatible hydrogels.
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BBM-3C-089 | 3D F-PVA |
3D F-PVA consists of maleimide-functionalized polyvinyl alcohol (Mal-PVA), which can be used together with other components PEG-Link or CD-Link to set up cell-compatible hydrogels.
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BBM-3C-090 | 3D 10x CB-Buffer (pH 5.5) |
3D 10x CB-Buffer (pH 5.5), a buffer solution, provides a cell environment at pH 5.5 for the formation of fast-gelling 3D hydrogels.
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BBM-3C-091 | 3D 10x CB Buffer (pH 7.2) |
3D 10x CB-Buffer (pH 7.2), a buffer solution, provides a cell environment at pH 7.2 for the formation of slow-gelling 3D hydrogels.
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BBM-3C-092 | 3D Cell Culture Kit |
3D Cell Culture Ki is a ready-to-use bioactive gel that simulates the microenvironment and morphological structure of three-dimensional tissues in vivo to provide a three-dimensional microenvironment similar to the in vivo extracellular matrix for cell culture in vitro and in vivo experiments, supporting the three-dimensional growth of various cells.
It does not contain antigenic substances and animal-derived ingredients with no immunogenicity, stable and clear ingredients, a small difference between batches, highly reproducible experiments, and is easy to operate, only needs to operate at RT with no ice required.
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BBM-3C-093 | 3D Cell and Organoid Culturing Gel Kit |
3D Cell and Organoid Culturing Gel Kit is constructed with synthetic biological raw materials to simulate the microenvironment of human tissue. It has stable quality and freely adjustable colloid hardness, easy operation, high culture stability, high cell recovery rate, and high biocompatibility.
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BBM-3C-094 | Collagen Hydrogel (Rat) |
Collagen Hydrogel from Ace Therapeutics is a biocompatible complex of type I collagen fibers. These products contain a variety of purified, high-quality collagens derived from biological tissues, which facilitate gel formation and help the cultivation of 3D tissue models. When using this type of product for 3D culture, it will not break or tear easily. Collagen Hydrogel (Rat) contains purified collagens from rat tendons.
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BBM-3C-095 | Collagen Hydrogel (Soft-Rat) |
Collagen Hydrogel from Ace Therapeutics is a biocompatible complex of type I collagen fibers. These products contain a variety of purified, high-quality collagens derived from biological tissues, which facilitate gel formation and help the cultivation of 3D tissue models. When using this type of product for 3D culture, it will not break or tear easily. Collagen Hydrogel (Soft-Rat) contains purified collagens from rat tendons.
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BBM-3C-096 | Collagen Hydrogel (Soft+-Rat) |
Collagen Hydrogel from Ace Therapeutics is a biocompatible complex of type I collagen fibers. These products contain a variety of purified, high-quality collagens derived from biological tissues, which facilitate gel formation and help the cultivation of 3D tissue models. When using this type of product for 3D culture, it will not break or tear easily. Collagen Hydrogel (Soft+-Rat) contains purified collagens from rat tendons.
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BBM-3C-097 | Collagen Hydrogel (Human) |
Collagen Hydrogel from Ace Therapeutics is a biocompatible complex of type I collagen fibers. These products contain a variety of purified, high-quality collagens derived from biological tissues, which facilitate gel formation and help the cultivation of 3D tissue models. When using this type of product for 3D culture, it will not break or tear easily. Collagen Hydrogel (Human) contains purified collagens from the human tendon.
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BBM-3C-098 | Collagen Hydrogel (Soft-Human) |
Collagen Hydrogel from Ace Therapeutics is a biocompatible complex of type I collagen fibers. These products contain a variety of purified, high-quality collagens derived from biological tissues, which facilitate gel formation and help the cultivation of 3D tissue models. When using this type of product for 3D culture, it will not break or tear easily. Collagen Hydrogel (Soft-Human) contains purified collagens from the human tendon.
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BBM-3C-099 | Collagen Hydrogel (Soft+-Human) |
Collagen Hydrogel from Ace Therapeutics is a biocompatible complex of type I collagen fibers. These products contain a variety of purified, high-quality collagens derived from biological tissues, which facilitate gel formation and help the cultivation of 3D tissue models. When using this type of product for 3D culture, it will not break or tear easily. Collagen Hydrogel (Soft+-Human) contains purified collagens from the human tendon.
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BBM-3C-100 | Collagen Hydrogel (Bovine) |
Collagen Hydrogel from Ace Therapeutics is a biocompatible complex of type I collagen fibers. These products contain a variety of purified, high-quality collagens derived from biological tissues, which facilitate gel formation and help the cultivation of 3D tissue models. When using this type of product for 3D culture, it will not break or tear easily. Collagen Hydrogel (Bovine) contains purified collagens from the bovine tendon.
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BBM-3C-101 | Collagen Hydrogel (Soft-Bovine) |
Collagen Hydrogel from Ace Therapeutics is a biocompatible complex of type I collagen fibers. These products contain a variety of purified, high-quality collagens derived from biological tissues, which facilitate gel formation and help the cultivation of 3D tissue models. When using this type of product for 3D culture, it will not break or tear easily. Collagen Hydrogel (Soft-Bovine) contains purified collagens from the bovine tendon.
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