The BBB is a specialized barrier in the brain that regulates the entry of molecules and cells from the bloodstream into the brain. It plays a crucial role in protecting the brain from harmful substances and maintaining its homeostasis.
Traditional 2D cell model of BBB culture is performed on simple, nonporous two-dimensional (2D) surfaces. Despite the method being easy and convenient, can result in certain well-documented artifacts. The 3D BBB model culture substrate refers to the three-dimensional culture system used for culturing and studying the blood-brain barrier (BBB) model in vitro, which aims to mimic the physiological conditions of the brain's microenvironment, allowing researchers to study BBB function and dysfunction in a controlled laboratory setting. It typically consists of a specialized culture substrate that supports the growth and differentiation of brain endothelial cells, which form the main component of the BBB. The substrate is often coated with extracellular matrix proteins like collagen or laminin to provide a suitable surface for cell attachment and growth.
A well-established method for culturing 3D BBB models is to culture cells on structural scaffolds, which are typically composed of biopolymers, such as 3D hydrogels and collagens, arranged to mimic the physiological extracellular matrix (ECM).
Highlighted below are the types of brackets Ace Therapeutics offers for 3D BBB model culture.
Click on the Links to Access Our 3D BBB Model Culture Substrate:
| Cat.# | Name | Description | Price |
|---|---|---|---|
| BBM-3C-110 | ECM Gel from Engelbreth-Holm-Swarm Murine Sarcoma |
ECM Gel From Engelbreth-Holm-Swarm Murine Sarcoma is prepared from Engelbreth-Holm-Swarm sarcoma in mice for 3D cell culture, without phenol red.
|
inquiry |
| BBM-3C-111 | 3D Cell Culture Gel solution |
3D Cell Culture Gel Solution is a ready-to-use collagen solution that forms a solid gel by heating it to 37°C for cell culture.
|
inquiry |
| BBM-3C-112 | 3D RGD-CD Hydrogel Kits |
3D Hydrogel Kits (Pre-Configured), a pre-configured 3D hydrogel system, consists of RGD (arginyl glycyl aspartate) degradable polymer and CD cell degradable cross-linking agent. When RGD and CD cross-linkers are mixed, they cross-link into a gel.
|
inquiry |
| BBM-3C-114 | 3D PVA-PEG Hydrogel Kits |
3D Hydrogel Kits (Pre-Configured), a pre-configured 3D hydrogel system, consists of maleimide-functionalized PVA and PEG non-cell-degradable crosslinker. When PVA polymer and CD cross-linkers are mixed, they cross-link into a gel.
|
inquiry |
| BBM-3C-016 | Bovine Collagen Type VI, Lyophilized, 0.1mg |
Bovine Collagen Type VI, Lyophilized, 0.1mg from Ace Therapeutics is purified from the bovine placenta.
The product is the major collagenous component of microfibrils in elastic fibers and in a larger variety of tissues, which consist of two α-chains of ca.
|
inquiry |
| BBM-3C-017 | Bovine Collagen Type I (Atelocollagen) , 30 mg |
Bovine Collagen Type I (Atelocollagen) from Ace Therapeutics is purified from bovine tendons.
Type I collagen is found in connective tissues and is the major component of tensile strength of the extracellular matrix (ECM). The product is widely used as a thin layer on tissue-culture surfaces to enhance the attachment and proliferation of a variety of cells including endothelial cells, fibroblasts, hepatocytes, epithelial cells, etc. In addition, the product can self-assemble into a 3-D supramolecular gel in vitro as an ideal biological scaffold.
|
inquiry |
| BBM-3C-018 | Mouse Collagen Type I (Atelocollagen), 1 mg |
Mouse Collagen Type I (Atelocollagen) from Ace Therapeutics is purified from the mouse tail tendon.
Type I collagen is found in connective tissues and is the major component of tensile strength of the extracellular matrix (ECM). The product is widely used as a thin layer on tissue-culture surfaces to enhance the attachment and proliferation of a variety of cells including endothelial cells, fibroblasts, hepatocytes, epithelial cells, etc. In addition, the product can self-assemble into a 3-D supramolecular gel in vitro as an ideal biological scaffold.
|
inquiry |
| BBM-3C-019 | Rat Collagen Type I (Atelocollagen), 30 mg |
Rat Collagen Type I (Atelocollagen) from Ace Therapeutics is purified from the rat tail tendon.
Type I collagen is found in connective tissues and is the major component of tensile strength of the extracellular matrix (ECM). The product is widely used as a thin layer on tissue-culture surfaces to enhance the attachment and proliferation of a variety of cells including endothelial cells, fibroblasts, hepatocytes, epithelial cells, etc. In addition, the product can self-assemble into a 3-D supramolecular gel in vitro as an ideal biological scaffold.
|
inquiry |
| BBM-3C-020 | Bovine Collagen Type I and III, 10 mg |
Bovine Collagen Type I and III, 10 mg from Ace Therapeutics is purified from calf skin.
Type I collagen is the most abundant collagen and is found in connective tissues including tendons, ligaments, dermis, and blood vessels. Type III collagen is the second most abundant collagen in tissues and is found most commonly in tissues exhibiting elastic properties such as skin, lungs, intestinal walls, and walls of blood vessels, which resembles other fibrillar collagens in structure and function.
|
inquiry |
| BBM-3C-021 | Canine Collagen Type I and III, 10 mg |
Canine Collagen Type I and III, 10 mg from Ace Therapeutics is purified from canine collagen.
Type I collagen is the most abundant collagen and is found in connective tissues including tendons, ligaments, dermis, and blood vessels. Type III collagen is the second most abundant collagen in tissues and is found most commonly in tissues exhibiting elastic properties such as skin, lungs, intestinal walls, and walls of blood vessels, which resembles other fibrillar collagens in structure and function.
|
inquiry |
| BBM-3C-022 | Mouse Collagen Type I and III, 5 mg |
Mouse Collagen Type I and III, 5 mg from Ace Therapeutics is purified from rom tail tendons of the mouse.
Type I collagen is the most abundant collagen and is found in connective tissues including tendons, ligaments, dermis, and blood vessels. Type III collagen is the second most abundant collagen in tissues and is found most commonly in tissues exhibiting elastic properties such as skin, lungs, intestinal walls, and walls of blood vessels, which resembles other fibrillar collagens in structure and function.
|
inquiry |
| BBM-3C-023 | Porcine Collagen Type I and III, 10 mg |
Porcine Collagen Type I and III, 10 mg from Ace Therapeutics is purified from pig’s tissue.
Type I collagen is the most abundant collagen and is found in connective tissues including tendons, ligaments, dermis, and blood vessels. Type III collagen is the second most abundant collagen in tissues and is found most commonly in tissues exhibiting elastic properties such as skin, lungs, intestinal walls, and walls of blood vessels, which resembles other fibrillar collagens in structure and function.
|
inquiry |
| BBM-3C-024 | Rat Collagen Type I and III, 10 mg |
Rat Collagen Type I and III, 10 mg from Ace Therapeutics is purified from rat tissue.
Type I collagen is the most abundant collagen and is found in connective tissues including tendons, ligaments, dermis, and blood vessels. Type III collagen is the second most abundant collagen in tissues and is found most commonly in tissues exhibiting elastic properties such as skin, lungs, intestinal walls, and walls of blood vessels, which resembles other fibrillar collagens in structure and function.
|
inquiry |
| BBM-3C-025 | Bovine Collagen Type I, 10 mg |
Bovine Collagen Type I, 10 mg from Ace Therapeutics is purified from bovine skin.
Type I collagen is found in connective tissues and is the major component of tensile strength of the extracellular matrix (ECM). The product is widely used as a thin layer on tissue-culture surfaces to enhance the attachment and proliferation of a variety of cells including endothelial cells, fibroblasts, hepatocytes, epithelial cells, etc. In addition, the product can self-assemble into a 3-D supramolecular gel in vitro as an ideal biological scaffold.
|
inquiry |
| BBM-3C-026 | Goat Collagen Type I, 10 mg |
Goat Collagen Type I, 10 mg from Ace Therapeutics is purified from goat tissue.
Type I collagen is found in connective tissues and is the major component of tensile strength of the extracellular matrix (ECM). The product is widely used as a thin layer on tissue-culture surfaces to enhance the attachment and proliferation of a variety of cells including endothelial cells, fibroblasts, hepatocytes, epithelial cells, etc. In addition, the product can self-assemble into a 3-D supramolecular gel in vitro as an ideal biological scaffold.
|
inquiry |
Ace Therapeutics is a global leading provider of stroke research services. We are committed to accelerating progress in stroke research and drug development.