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The BBB is a specialized barrier in the brain that regulates the entry of molecules and cells from the bloodstream into the brain. It plays a crucial role in protecting the brain from harmful substances and maintaining its homeostasis.
Traditional 2D cell model of BBB culture is performed on simple, nonporous two-dimensional (2D) surfaces. Despite the method being easy and convenient, can result in certain well-documented artifacts. The 3D BBB model culture substrate refers to the three-dimensional culture system used for culturing and studying the blood-brain barrier (BBB) model in vitro, which aims to mimic the physiological conditions of the brain's microenvironment, allowing researchers to study BBB function and dysfunction in a controlled laboratory setting. It typically consists of a specialized culture substrate that supports the growth and differentiation of brain endothelial cells, which form the main component of the BBB. The substrate is often coated with extracellular matrix proteins like collagen or laminin to provide a suitable surface for cell attachment and growth.
A well-established method for culturing 3D BBB models is to culture cells on structural scaffolds, which are typically composed of biopolymers, such as 3D hydrogels and collagens, arranged to mimic the physiological extracellular matrix (ECM).
Highlighted below are the types of brackets Ace Therapeutics offers for 3D BBB model culture.
Click on the Links to Access Our 3D BBB Model Culture Substrate:
Cat.# | Name | Description | Price |
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BBM-3C-092 | 3D Cell Culture Kit |
3D Cell Culture Ki is a ready-to-use bioactive gel that simulates the microenvironment and morphological structure of three-dimensional tissues in vivo to provide a three-dimensional microenvironment similar to the in vivo extracellular matrix for cell culture in vitro and in vivo experiments, supporting the three-dimensional growth of various cells.
It does not contain antigenic substances and animal-derived ingredients with no immunogenicity, stable and clear ingredients, a small difference between batches, highly reproducible experiments, and is easy to operate, only needs to operate at RT with no ice required.
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BBM-3C-093 | 3D Cell and Organoid Culturing Gel Kit |
3D Cell and Organoid Culturing Gel Kit is constructed with synthetic biological raw materials to simulate the microenvironment of human tissue. It has stable quality and freely adjustable colloid hardness, easy operation, high culture stability, high cell recovery rate, and high biocompatibility.
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BBM-3C-094 | Collagen Hydrogel (Rat) |
Collagen Hydrogel from Ace Therapeutics is a biocompatible complex of type I collagen fibers. These products contain a variety of purified, high-quality collagens derived from biological tissues, which facilitate gel formation and help the cultivation of 3D tissue models. When using this type of product for 3D culture, it will not break or tear easily. Collagen Hydrogel (Rat) contains purified collagens from rat tendons.
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BBM-3C-095 | Collagen Hydrogel (Soft-Rat) |
Collagen Hydrogel from Ace Therapeutics is a biocompatible complex of type I collagen fibers. These products contain a variety of purified, high-quality collagens derived from biological tissues, which facilitate gel formation and help the cultivation of 3D tissue models. When using this type of product for 3D culture, it will not break or tear easily. Collagen Hydrogel (Soft-Rat) contains purified collagens from rat tendons.
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BBM-3C-096 | Collagen Hydrogel (Soft+-Rat) |
Collagen Hydrogel from Ace Therapeutics is a biocompatible complex of type I collagen fibers. These products contain a variety of purified, high-quality collagens derived from biological tissues, which facilitate gel formation and help the cultivation of 3D tissue models. When using this type of product for 3D culture, it will not break or tear easily. Collagen Hydrogel (Soft+-Rat) contains purified collagens from rat tendons.
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BBM-3C-097 | Collagen Hydrogel (Human) |
Collagen Hydrogel from Ace Therapeutics is a biocompatible complex of type I collagen fibers. These products contain a variety of purified, high-quality collagens derived from biological tissues, which facilitate gel formation and help the cultivation of 3D tissue models. When using this type of product for 3D culture, it will not break or tear easily. Collagen Hydrogel (Human) contains purified collagens from the human tendon.
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BBM-3C-098 | Collagen Hydrogel (Soft-Human) |
Collagen Hydrogel from Ace Therapeutics is a biocompatible complex of type I collagen fibers. These products contain a variety of purified, high-quality collagens derived from biological tissues, which facilitate gel formation and help the cultivation of 3D tissue models. When using this type of product for 3D culture, it will not break or tear easily. Collagen Hydrogel (Soft-Human) contains purified collagens from the human tendon.
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BBM-3C-099 | Collagen Hydrogel (Soft+-Human) |
Collagen Hydrogel from Ace Therapeutics is a biocompatible complex of type I collagen fibers. These products contain a variety of purified, high-quality collagens derived from biological tissues, which facilitate gel formation and help the cultivation of 3D tissue models. When using this type of product for 3D culture, it will not break or tear easily. Collagen Hydrogel (Soft+-Human) contains purified collagens from the human tendon.
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BBM-3C-100 | Collagen Hydrogel (Bovine) |
Collagen Hydrogel from Ace Therapeutics is a biocompatible complex of type I collagen fibers. These products contain a variety of purified, high-quality collagens derived from biological tissues, which facilitate gel formation and help the cultivation of 3D tissue models. When using this type of product for 3D culture, it will not break or tear easily. Collagen Hydrogel (Bovine) contains purified collagens from the bovine tendon.
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BBM-3C-101 | Collagen Hydrogel (Soft-Bovine) |
Collagen Hydrogel from Ace Therapeutics is a biocompatible complex of type I collagen fibers. These products contain a variety of purified, high-quality collagens derived from biological tissues, which facilitate gel formation and help the cultivation of 3D tissue models. When using this type of product for 3D culture, it will not break or tear easily. Collagen Hydrogel (Soft-Bovine) contains purified collagens from the bovine tendon.
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BBM-3C-102 | Collagen Hydrogel (Soft+-Bovine) |
Collagen Hydrogel from Ace Therapeutics is a biocompatible complex of type I collagen fibers. These products contain a variety of purified, high-quality collagens derived from biological tissues, which facilitate gel formation and help the cultivation of 3D tissue models. When using this type of product for 3D culture, it will not break or tear easily. Collagen Hydrogel (Soft+-Bovine) contains purified collagens from the bovine tendon.
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BBM-3C-103 | 3D Cell Culture Hydrogel (100% Peptide) |
3D Cell Culture Hydrogel (100% Peptide) from Ace Therapeutics is a peptide synthetic hydrogel without any animal-derived or bioactive ingredients that can be used as an ideal three-dimensional cell culture scaffold.
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BBM-3C-105 | 3D Cell Culture Matrix Kit (Alginate Hydrogel) |
3D Cell Culture Matrix Kit (Alginate Hydrogel) is used to artificially create a three-dimensional (3D) cell culture environment. The foundation of this kit is alginate, an anionic polysaccharide sourced from algae cell walls.
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BBM-3C-108 | 3D Cell Culture Hydrogels Kit (Peptides) |
3D Cell Culture Hydrogels Kit (Peptides) is a synthetic peptide hydrogel free of animal origin, which can simulate the extracellular matrix of different tissues for 3D cell cultures.
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BBM-3C-109 | ECM Gel from Engelbreth-Holm-Swarm Murine Sarcoma |
ECM Gel From Engelbreth-Holm-Swarm Murine Sarcoma is prepared from Engelbreth-Holm-Swarm sarcoma in mice for 3D cell culture.
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