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ZL006

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Specification

Cat. No.

SMD1262

Related Diseases

Depression

Product Name

ZL006

Size

10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; Click to view more sizes and prices

Price

Inquiry

Availability

2 Weeks

Description

ZL006 is a PSD95-nNOS protein-protein interaction inhibitor. ZL006 (EC50: 12.88 μM) directly inhibited binding of purified PSD95 and nNOS proteins in AlphaScreen without altering binding of PSD95 to ErbB4. ZL006 preferentially suppressed phase 2A pain behavior in the formalin test and suppressed allodynia induced by intraplantar complete Freund's adjuvant administration. Disrupting PSD95-nNOS protein-protein interactions is effective in attenuating pathological pain without producing unwanted side effects (i.e. motor ataxia) associated with NMDAR antagonists. (

CAS Number

1181226-02-7

Chemical Formula

C14H11Cl2NO4

Exact Mass

327.0065

Molecular Weight

328.145

Elemental Analysis

C, 51.24; H, 3.38; Cl, 21.61; N, 4.27; O, 19.50

Synonym

ZL006; ZL-006; ZL 006.

IUPAC/Chemical Name

4-(3,5-Dichloro-2-hydroxy-benzylamino)-2-hydroxybenzoic acid

InChi Key

RTEYSQSXRFVKTJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H11Cl2NO4/c15-8-3-7(13(19)11(16)4-8)6-17-9-1-2-10(14(20)21)12(18)5-9/h1-5,17-19H,6H2,(H,20,21)

SMILES Code

O=C(O)C1=CC=C(NCC2=CC(Cl)=CC(Cl)=C2O)C=C1O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.