Related Diseases
Bipolar Disorder
Related Diseases
Schizophrenia
Related Diseases
Depression
Product Name
Ziprasidone HCl hydrate
Description
Ziprazidone is approved for the treatment of schizophrenia, and acute mania and mixed states associated with bipolar disorder. Its intramuscular injection form is approved for acute agitation in schizophrenic patients for whom treatment with just ziprasidone is appropriate. The mechanism of action of ziprasidone, as with other drugs having efficacy in schizophrenia, is unknown. However, it has been proposed that this drug's efficacy in schizophrenia is mediated through a combination of dopamine type 2 (D2) and serotonin type 2 (5HT2) antagonism. As with other drugs having efficacy in bipolar disorder, the mechanism of action of ziprasidone in bipolar disorder is unknown.
CAS Number
138982-67-9 (HCl hydrate)
Chemical Formula
C21H24Cl2N4O2S
Elemental Analysis
C, 53.96; H, 5.18; Cl, 15.17; N, 11.99; O, 6.85; S, 6.86
Synonym
Ziprasidone HCl hydrate; CP88059; CP-88059; CP 88059; CP-88,059; CP-88,059-01; CP88059 hydrochloride; Ziprasidone HCl,
IUPAC/Chemical Name
5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one Hydrochloride Monohydrate
InChi Key
ZCBZSCBNOOIHFP-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H21ClN4OS.ClH.H2O/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21;;/h1-4,11,13H,5-10,12H2,(H,23,27);1H;1H2
SMILES Code
O=C1NC2=C(C=C(CCN3CCN(C4=NSC5=C4C=CC=C5)CC3)C(Cl)=C2)C1.[H]Cl.[H]O[H]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).
HS Tariff Code
2934.99.9001