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VU6009453

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Specification

Cat. No.

SMD1761

Related Diseases

Schizophrenia

Product Name

VU6009453

Size

Customizable

Price

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Description

VU6009453 is a novel M4 positive allosteric modulator (PAM). VU6009453 showed good potency (EC50=383 nM) and excellent CNS penetration (rat Kp=3.4, Kp,uu=0.84).

CAS Number

2148929-11-5

Chemical Formula

C21H21ClN4O2

Exact Mass

396.1353

Molecular Weight

396.88

Elemental Analysis

C, 63.55; H, 5.33; Cl, 8.93; N, 14.12; O, 8.06

Synonym

VU6009453; VU 6009453; VU-6009453

IUPAC/Chemical Name

N-(1-(5-Chloro-2-methoxypyridin-4-yl)azetidin-3-yl)-2,4-dimethylquinoline-6-carboxamide

InChi Key

NVGMPSJSLKIVIT-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H21ClN4O2/c1-12-6-13(2)24-18-5-4-14(7-16(12)18)21(27)25-15-10-26(11-15)19-8-20(28-3)23-9-17(19)22/h4-9,15H,10-11H2,1-3H3,(H,25,27)

SMILES Code

O=C(C1=CC=C2N=C(C)C=C(C)C2=C1)NC3CN(C4=CC(OC)=NC=C4Cl)C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.03.00

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.