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VU0467485

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Specification

Cat. No.

SMD1759

Related Diseases

Schizophrenia

Product Name

VU0467485

Size

10.0mg; 50.0mg

Price

Inquiry

Availability

2 Weeks

Description

VU0467485, also known as AZ13713945, is a potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulators (PAMs). VU0467485 represents a major advance in the field, as the first potent M4 PAM to overcome major species differences in potency while maintaining high selectivity versus M2 (rat, dog, cyno, and human EC50s > 30 μM), CNS penetration, and in vivo efficacy. VU0467485 showed robust efficacy in behavioral models that was evaluated as a preclinical candidate.

CAS Number

1451994-10-7

Chemical Formula

C17H17FN4O2S

Exact Mass

360.1056

Molecular Weight

360.4074

Elemental Analysis

C, 56.65; H, 4.75; F, 5.27; N, 15.55; O, 8.88; S, 8.90

Synonym

VU 0467485, VU-0467485, VU0467485, AZ13713945, AZ-13713945, AZ 13713945

IUPAC/Chemical Name

5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide

InChi Key

VFNHDIWHQGVWLL-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H17FN4O2S/c1-8-9(2)21-22-17-13(8)14(19)15(25-17)16(23)20-7-10-4-5-12(24-3)11(18)6-10/h4-6H,7,19H2,1-3H3,(H,20,23)

SMILES Code

O=C(C1=C(N)C2=C(C)C(C)=NN=C2S1)NCC3=CC=C(OC)C(F)=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.