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VU 0650786

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Specification

Cat. No.

SMD1257

Related Diseases

Depression

Product Name

VU 0650786

Size

Customizable

Price

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Description

VU 0650786 is a mGlu3 negative allosteric modulator. VU 0650786 has an mGlu2 IC50 of greater than 30 uM and mGlu3 IC50 of 392 nM, suggesting that it is highly selective for mGlu2 and mGlu3.

CAS Number

NONE

Chemical Formula

C18H15ClFN5O2

Exact Mass

387.0898

Molecular Weight

387.8

Elemental Analysis

C, 55.75; H, 3.90; Cl, 9.14; F, 4.90; N, 18.06; O, 8.25

Synonym

VU 0650786; VU-0650786; VU0650786

IUPAC/Chemical Name

(R)-2-(((5-chloropyridin-2-yl)oxy)methyl)-5-(2-fluoropyridin-3-yl)-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one

InChi Key

RXRVCJFGSOVYLG-LLVKDONJSA-N

InChi Code

InChI=1S/C18H15ClFN5O2/c1-11-9-24(14-3-2-6-21-17(14)20)18(26)15-7-13(23-25(11)15)10-27-16-5-4-12(19)8-22-16/h2-8,11H,9-10H2,1H3/t11-/m1/s1

SMILES Code

ClC1=CC=C(OCC2=NN([C@H](C)CN(C3=C(F)N=CC=C3)C4=O)C4=C2)N=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.