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Vortioxetine free base

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Specification

Cat. No.

SMD1216

Related Diseases

Depression

Product Name

Vortioxetine free base

Size

500.0mg; 1.0g; 2.0g; 5.0g

Price

Inquiry

Availability

2 Weeks

Description

Vortioxetine, also known as Lu AA21004, is an atypical antidepressant, and was approved in 2013 by the U.S. FDA for the treatment of major depressive disorder (MDD) in adults. Vortioxetine is a so-called "serotonin modulator and stimulator." It has been shown to possess the following pharmacological actions: Serotonin transporter (SERT) blocker (i.e. serotonin reuptake inhibitor (SRI)) — Ki (binding affinity) = 1.6 nM, IC50 = 5.4 nM; Norepinephrine transporter (NET) blocker — Ki = 113 nM; 5-HT1A receptor high-efficacy partial agonist/near-full agonist — Ki = 15 nM, IA = 80%; 5-HT1B receptor partial agonist — Ki = 33 nM; 5-HT1D receptor antagonist — Ki = 54 nM; 5-HT3A receptor antagonist — Ki = 3.7 nM; 5-HT7 receptor antagonist — Ki = 19 nM.

CAS Number

508233-74-7 (free base)

Chemical Formula

C18H22N2S

Exact Mass

298.1504

Molecular Weight

298.45

Elemental Analysis

C, 72.44; H, 7.43; N, 9.39; S, 10.74

Synonym

LuAA21004; LuAA 21004; LuAA-21004; Lu-AA21004; Lu AA21004; AA21004; AA-21004; AA 21004; Vortioxetine; Brintellix.

IUPAC/Chemical Name

1-[2-(2,4-Dimethylphenyl)sulfanylphenyl]piperazine

InChi Key

YQNWZWMKLDQSAC-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H22N2S/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20/h3-8,13,19H,9-12H2,1-2H3

SMILES Code

CC1=CC=C(SC2=CC=CC=C2N3CCNCC3)C(C)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.