Related Diseases
Insomnia
Product Name
Vornorexant hydrate
Description
Vornorexant, also known as ORN-0829 and TS-142, is a potent dual orexin 1/2 receptor antagonist for the treatment of insomnia. Vornorexant is a dual orexin OX1 and OX2 receptor antagonist (DORA). Vornorexant has a time to peak of 2.5 hours and a relatively short elimination half-life of 1.3 to 3.3 hours. It was designed to have a short half-life and duration in order to reduce next-day side effects like
CAS Number
1793073-92-3 (hydrate)
Chemical Formula
C23H24FN7O3
Elemental Analysis
C, 59.35; H, 5.20; F, 4.08; N, 21.06; O, 10.31
Synonym
ORN-0829 hydrate; ORN0829; ORN 0829; ORN-0829; TS-142; TS 142; TS142; Vornorexant;
IUPAC/Chemical Name
Methanone, ((2S)-2-((3-(5-fluoro-2-pyridinyl)-1H-pyrazol-1-yl)methyl)dihydro-2H-1,3-oxazin-3(4H)-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)-, hydrate (1:1)
InChi Key
UFULGSDLQZYMCH-FTBISJDPSA-N
InChi Code
InChI=1S/C23H22FN7O2.H2O/c1-16-3-6-21(31-26-8-9-27-31)18(13-16)23(32)30-10-2-12-33-22(30)15-29-11-7-20(28-29)19-5-4-17(24)14-25-19;/h3-9,11,13-14,22H,2,10,12,15H2,1H3;1H2/t22-;/m0./s1
SMILES Code
O=C(N1[C@H](CN2N=C(C3=NC=C(F)C=C3)C=C2)OCCC1)C4=CC(C)=CC=C4N5N=CC=N5.[H]O[H]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).
HS Tariff Code
2934.99.9001