Inquiry

* Name

Phone

* Email

* Services or Products of Interest

Project Description

* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

* Tick to confirm the Research Use Only (RUO) statement.

Vornorexant free base

Inquiry

Specification

Cat. No.

SMD1323

Related Diseases

Insomnia

Product Name

Vornorexant free base

Size

5.0mg; 10.0mg

Price

Inquiry

Availability

2 Weeks

Description

Vornorexant, also known as ORN-0829 and TS-142, is a potent dual orexin 1/2 receptor antagonist for the treatment of insomnia. Vornorexant is a dual orexin OX1 and OX2 receptor antagonist (DORA). Vornorexant has a time to peak of 2.5 hours and a relatively short elimination half-life of 1.3 to 3.3 hours. It was designed to have a short half-life and duration in order to reduce next-day side effects like

CAS Number

1517965-94-4 (free base)

Chemical Formula

C23H22FN7O2

Exact Mass

447.1819

Molecular Weight

447.47

Elemental Analysis

C, 61.74; H, 4.96; F, 4.25; N, 21.91; O, 7.15

Synonym

Vornorexant free base; ORN0829; ORN 0829; ORN-0829; TS-142; TS 142; TS142;

IUPAC/Chemical Name

Methanone, ((2S)-2-((3-(5-fluoro-2-pyridinyl)-1H-pyrazol-1-yl)methyl)dihydro-2H-1,3-oxazin-3(4H)-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)-

InChi Key

AEZZJXJIJFSUEM-QFIPXVFZSA-N

InChi Code

InChI=1S/C23H22FN7O2/c1-16-3-6-21(31-26-8-9-27-31)18(13-16)23(32)30-10-2-12-33-22(30)15-29-11-7-20(28-29)19-5-4-17(24)14-25-19/h3-9,11,13-14,22H,2,10,12,15H2,1H3/t22-/m0/s1

SMILES Code

O=C(N1[C@H](CN2N=C(C3=NC=C(F)C=C3)C=C2)OCCC1)C4=CC(C)=CC=C4N5N=CC=N5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.