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Vexibinol

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Specification

Cat. No.

SMD1228

Related Diseases

Depression

Product Name

Vexibinol

Size

1.0mg; 5.0mg; 10.0mg; 25.0mg

Price

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Availability

2 Weeks

Description

Vexibinol is a flavonoid that has been found in S. flavescens and has diverse biological activities. It is active against 21 strains of methicillin-resistant S. aureus (MRSA; MICs = 3.13-6.25 µg/ml) and inhibits the activities of α-glucosidase and β-amylase (Kis = 5.6 and 30.6 µM, respectively). Vexibinol is cytotoxic to HL-60 and HepG2 cancer cells (IC50s = 12.5 and 13.3 µM, respectively) and induces apoptosis in HL-60 cells when used at concentrations of 10 or 25 µM. It reduces LPS-induced production of prostaglandin E2 (PGE2) in RAW 264.7 cells when used at concentrations ranging from 1 to 50 µM. Vexibinol (250 mg/kg) inhibits carrageenan-induced paw edema in rats.

CAS Number

97938-30-2

Chemical Formula

C25H28O6

Exact Mass

424.1886

Molecular Weight

424.493

Elemental Analysis

C, 70.74; H, 6.65; O, 22.61

Synonym

Vexibinol; (-)-Vexibinol; Kushenol F; Kushnol F; Norkurarinone; Sophoraflavanone G;

IUPAC/Chemical Name

4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(2,4-dihydroxyphenyl)-8-(5-methyl-2-(1-methylethenyl)-4-hexenyl)-, (S-(R*,S*))-

InChi Key

XRYVAQQLDYTHCL-CMJOXMDJSA-N

InChi Code

InChI=1S/C25H28O6/c1-13(2)5-6-15(14(3)4)9-18-20(28)11-21(29)24-22(30)12-23(31-25(18)24)17-8-7-16(26)10-19(17)27/h5,7-8,10-11,15,23,26-29H,3,6,9,12H2,1-2,4H3/t15-,23+/m1/s1

SMILES Code

O=C1C[C@@H](C2=CC=C(O)C=C2O)OC3=C(C[C@H](C(C)=C)C/C=C(C)\C)C(O)=CC(O)=C13

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.03.00

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.