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Trazium Esilate

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Specification

Cat. No.

SMD1223

Related Diseases

Depression

Product Name

Trazium Esilate

Size

Customizable

Price

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Description

Trazium esilate, also known as EGYT-3615, is an adrenergic receptor antagonist potentially for the treatment of major depressive disorder. Trazium esilate is a weak displacer on a1-, a2- and D2-receptors, however, it induced a2-receptor desenzitization after repeated treatment. It had no influence on rat brain cortical noradrenaline and striatal dopamine release evoked by high K+ concentration, but it increased the spontaneous dopamine outflow in rat striatum.

CAS Number

97110-59-3

Chemical Formula

C19H18ClN3O4S

Molecular Weight

419.88

Elemental Analysis

C, 54.35; H, 4.32; Cl, 8.44; N, 10.01; O, 15.24; S, 7.64

Synonym

Trazium esilate; EGYT-3615; EGYT3615; EGYT 3615

IUPAC/Chemical Name

1-(4-chlorophenyl)-1-hydroxy-1,4-dihydro-[1,2,4]triazino[6,1-a]isoquinolin-5-ium ethanesulfonate

InChi Key

SHXJBCWOVPAZQL-UHFFFAOYSA-M

InChi Code

InChI=1S/C17H13ClN3O.C2H6O3S/c18-14-7-5-13(6-8-14)17(22)16-15-4-2-1-3-12(15)9-10-21(16)20-11-19-17;1-2-6(3,4)5/h1-11,22H,(H,19,20);2H2,1H3,(H,3,4,5)/q+1;/p-1

SMILES Code

OC1(C2=CC=C(Cl)C=C2)N=CN[N+]3=CC=C4C=CC=CC4=C31.CCS(=O)([O-])=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.