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Tipepidine

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Specification

Cat. No.

SMD012

Related Diseases

ADHD

Related Diseases

Depression

Product Name

Tipepidine

Size

Customizable

Price

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Description

Tipepidine, also known as tipepidine hibenzate, is a synthetic, non-opioid antitussive and expectorant of the thiambutene class. It acts as an inhibitor of G protein-coupled inwardly-rectifying potassium channels (GIRKs). Tipepidine has recently garnered interest as a potential psychiatric drug. It is being investigated in depression, obsessive-compulsive disorder, and attention-deficit hyperactivity disorder (ADHD). Through inhibition of GIRK channels, tipepidine increases dopamine levels in the nucleus accumbens, but without increasing locomotor activity or producing methamphetamine-like behavioral sensitization, and this action appears to be at least partly responsible for its antidepressant-like effects in rodents.

CAS Number

5169-78-8 (free base)

Chemical Formula

C15H17NS2

Exact Mass

275.0802

Molecular Weight

275.43

Elemental Analysis

C, 65.41; H, 6.22; N, 5.09; S, 23.28

Synonym

Tipepidine; AT 327; AT-327; AT327; brand names Asverin, Antupex, Asvelik, Asvex, Bitiodin, Cofdenin A, Hustel, Nodal, Sotal.

IUPAC/Chemical Name

3-(Di-2-thienylmethylene)-1-methylpiperidine

InChi Key

JWIXXNLOKOAAQT-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H17NS2/c1-16-8-2-5-12(11-16)15(13-6-3-9-17-13)14-7-4-10-18-14/h3-4,6-7,9-10H,2,5,8,11H2,1H3

SMILES Code

CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.03.00

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.