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Tipepidine citrate

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Specification

Cat. No.

SMD005

Related Diseases

ADHD

Related Diseases

Depression

Product Name

Tipepidine citrate

Size

Customizable

Price

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Description

Tipepidine, also known as tipepidine hibenzate, is a synthetic, non-opioid antitussive and expectorant of the thiambutene class. It acts as an inhibitor of G protein-coupled inwardly-rectifying potassium channels (GIRKs). Tipepidine has recently garnered interest as a potential psychiatric drug. It is being investigated in depression, obsessive-compulsive disorder, and attention-deficit hyperactivity disorder (ADHD). Through inhibition of GIRK channels, tipepidine increases dopamine levels in the nucleus accumbens, but without increasing locomotor activity or producing methamphetamine-like behavioral sensitization, and this action appears to be at least partly responsible for its antidepressant-like effects in rodents.

CAS Number

14698-07-8 (citrate)

Chemical Formula

C21H25NO7S2

Exact Mass

467.1072

Molecular Weight

467.55

Elemental Analysis

C, 53.95; H, 5.39; N, 3.00; O, 23.95; S, 13.71

Synonym

Asverin citrate, Asverin-C, Asverine citrate, Bithiodine, Tipepidine citrate; AT 327; AT-327; AT327

IUPAC/Chemical Name

Piperidine, 3-(di-2-thienylmethylene)-1-methyl-, citrate (1:1)

InChi Key

WQOYJMWVNIGIQR-UHFFFAOYSA-N

InChi Code

1S/C15H17NS2.C6H8O7/c1-16-8-2-5-12(11-16)15(13-6-3-9-17-13)14-7-4-10-18-14;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-4,6-7,9-10H,2,5,8,11H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

SMILES Code

C1[N@@](CCC\C1=C(\c1cccs1)c1cccs1)C.C(C(CC(=O)O)(C(=O)O)O)C(=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.