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Taurodeoxycholic Acid-d4 sodium salt

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Specification

Cat. No.

SMD1754

Related Diseases

Schizophrenia

Product Name

Taurodeoxycholic Acid-d4 sodium salt

Size

1.0mg

Price

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Availability

2 Weeks

Description

Taurodeoxycholic acid-d4 is intended for use as an internal standard for the quantification of taurodeoxycholic acid by GC- or LC-MS. Taurodeoxycholic acid is a taurine-conjugated form of the secondary bile acid deoxycholic acid. Taurodeoxycholic acid stimulates chloride ion secretion through calcium-activated chloride ion channels and cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cell monolayers when applied basolaterally. Serum levels of taurodeoxycholic acid increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.

CAS Number

2410279-82-0 (sodium salt)

Chemical Formula

C26H40D4NNaO6S

Exact Mass

525.3038

Molecular Weight

525.7132

Elemental Analysis

C, 59.40; H, 9.20; N, 2.66; Na, 4.37; O, 18.26; S, 6.10

Synonym

Taurodeoxycholic Acid-d4 sodium salt; Taurodeoxycholic Acid d4 sodium salt; Sodium Taurodeoxycholate-d4; Sodium Taurodeoxycholate d4; TDCA-d4; TDCA d4;

IUPAC/Chemical Name

sodium 2-((R)-4-((3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl-2,2,4,4-d4)pentanamido)ethane-1-sulfonate

InChi Key

YXHRQQJFKOHLAP-YPYHFUETSA-M

InChi Code

InChI=1S/C26H45NO6S.Na/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3;/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);/q;+1/p-1/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-;/m1./s1/i10D2,14D2;

SMILES Code

[H][C@@]12[C@@]([H])(CC[C@@]3(C([2H])([C@@H](C([2H])(C[C@@]32C)[2H])O)[2H])[H])[C@@]([H])([C@@]4([C@H](C1)O)C)CC[C@@]4([C@@H](CCC(NCCS(=O)([O-])=O)=O)C)[H].[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.