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Taranabant (MK-0364)

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Specification

Cat. No.

SMD029

Related Diseases

Anorexia

Related Diseases

Anxiety

Product Name

Taranabant (MK-0364)

Size

Customizable

Price

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Description

Taranabant, aslo known as MK-0364, a cannabinoid receptor type 1 inverse agonist being investigated as a potential treatment for obesity due to its anorectic effects. Taranabant reduces abdominal pain and increases intestinal transit in mice. It was discovered by Merck & Co. In October 2008, Merck has stopped its phase III clinical trials with the drugs due to high level of central side effects, mainly depression and anxiety.

CAS Number

701977-09-5

Chemical Formula

C27H25ClF3N3O2

Exact Mass

515.1587

Molecular Weight

515.96

Elemental Analysis

C, 62.85; H, 4.88; Cl, 6.87; F, 11.05; N, 8.14; O, 6.20

Synonym

MK-0364, MK 0364, MK0364, Taranabant

IUPAC/Chemical Name

N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)butan-2-yl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide

InChi Key

QLYKJCMUNUWAGO-GAJHUEQPSA-N

InChi Code

InChI=1S/C27H25ClF3N3O2/c1-17(34-25(35)26(2,3)36-24-12-9-21(16-33-24)27(29,30)31)23(14-18-7-10-22(28)11-8-18)20-6-4-5-19(13-20)15-32/h4-13,16-17,23H,14H2,1-3H3,(H,34,35)/t17-,23+/m0/s1

SMILES Code

CC(OC1=NC=C(C(F)(F)F)C=C1)(C)C(N[C@H]([C@H](C2=CC=CC(C#N)=C2)CC3=CC=C(Cl)C=C3)C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.