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SOMCL-668

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Specification

Cat. No.

SMD1172

Related Diseases

Depression

Product Name

SOMCL-668

Size

Customizable

Price

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Description

SOMCL-668 is a novel potent and selective allosteric modulator of sigma-1 receptor. SOMCL-668 not only attenuated acute PCP-induced hyperactivity and PPI disruption, but also ameliorated social deficits and cognitive impairment induced by chronic PCP treatment. Pretreatment with the selective sigma-1 receptor antagonist BD1047 blocked the effects of SOMCL-668, indicating sigma-1 receptor-mediated responses. in vivo lower dose of SOMCL-668 exerted positive modulation of improvement in social deficits and cognitive impairment induced by the selective sigma-1 agonist PRE084. Also, SOMCL-668 reversed chronic PCP-induced down-regulation in expression of frontal cortical p-AKT/AKT, p-CREB/CREB and BDNF in wide-type but not sigma-1 knockout mice.

CAS Number

1422251-09-9

Chemical Formula

C17H19NO

Exact Mass

253.1467

Molecular Weight

253.345

Elemental Analysis

C, 80.60; H, 7.56; N, 5.53; O, 6.32

Synonym

SOMCL-668; SOMCL668; SOMCL 668;

IUPAC/Chemical Name

3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol

InChi Key

YQRZJWYKYUBPKB-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H19NO/c1-18-10-9-14-11-15(19)7-8-16(14)17(12-18)13-5-3-2-4-6-13/h2-8,11,17,19H,9-10,12H2,1H3

SMILES Code

OC1=CC=C2C(CCN(C)CC2C3=CC=CC=C3)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.