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Siramesine free base

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Specification

Cat. No.

SMD1205

Related Diseases

Depression

Product Name

Siramesine free base

Size

50.0mg; 100.0mg; 200.0mg

Price

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Availability

2 Weeks

Description

Siramesine, also known as Lu-28-179, is a potent sigma-2 receptor agonist. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation. Siramesine involves lysosomal leakage and oxidative stress.

CAS Number

147817-50-3 (free base)

Chemical Formula

C30H31FN2O

Exact Mass

454.242

Molecular Weight

454.5894

Elemental Analysis

C, 79.26; H, 6.87; F, 4.18; N, 6.16; O, 3.52

Synonym

Siramesine free base; Lu-28-179; Lu 28-179; Lu28-179; Lu-28179; Lu 28179; Lu28179.

IUPAC/Chemical Name

1'-(4-(1-(4-fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine]

InChi Key

XWAONOGAGZNUSF-UHFFFAOYSA-N

InChi Code

InChI=1S/C30H31FN2O/c31-25-12-14-26(15-13-25)33-21-23(27-9-2-4-11-29(27)33)7-5-6-18-32-19-16-30(17-20-32)28-10-3-1-8-24(28)22-34-30/h1-4,8-15,21H,5-7,16-20,22H2

SMILES Code

FC1=CC=C(N2C=C(CCCCN3CCC4(CC3)OCC5=CC=CC=C45)C6=C2C=CC=C6)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.