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Shu 9119

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Specification

Cat. No.

SMD381

Related Diseases

Anxiety

Product Name

Shu 9119

Size

1.0mg

Price

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Availability

2 Weeks

Description

Shu 9119 is an agonist of melanocortin receptor 1 (MC1R) and antagonist of MC4R (IC50s = 1.2 and 2.9 nM, respectively, for displacement of melanocortin). It induces cAMP formation in HEK293 cells expressing human MC1R (EC50 = 1.11 nM), but inhibits cAMP formation in cells expressing human MC4R.1 In rats, SHU9119 (24 nmol, i.c.v. per day for seven days) increases food intake, body weight, fat mass, and lean mass, with concomitant increases in blood glucose, insulin, and leptin levels via disrupted melanocortin signaling. Similarly, mice treated with SHU9119 (5 nmol/day, i.c.v.) exhibit food intake-independent increases in body weight and fat mass consequent to MC4R inhibition and subsequent brown adipose tissue dysfunction.

CAS Number

168482-23-3

Chemical Formula

C54H71N15O9

Exact Mass

1073.5559

Molecular Weight

1074.25

Elemental Analysis

C, 60.38; H, 6.66; N, 19.56; O, 13.40

Synonym

Shu 9119; Shu-9119; Shu9119;

IUPAC/Chemical Name

(2S)-N-((3S,6S,E)-3-((4H-imidazol-4-yl)methyl)-14-((2S)-2-((S)-2-((R)-2-amino-3-(naphthalen-2-yl)propanamido)-5-guanidinopentanamido)-3-(indolin-3-yl)propanamido)-2,5,8,15-tetraoxo-1,4,9-triazacyclopentadec-13-en-6-yl)-2-acetamidohexanamide

InChi Key

ORTUTLYEGOSCRP-ATNXLWBUSA-N

InChi Code

InChI=1S/C54H71N15O9/c1-3-4-15-40(63-31(2)70)48(73)68-45-27-46(71)59-21-10-9-17-41(50(75)69-53(78)44(67-52(45)77)26-36-29-58-30-62-36)65-51(76)43(25-35-28-61-39-16-8-7-14-37(35)39)66-49(74)42(18-11-22-60-54(56)57)64-47(72)38(55)24-32-19-20-33-12-5-6-13-34(33)23-32/h5-8,12-14,16-17,19-20,23,29-30,35-36,38,40,42-45,61H,3-4,9-11,15,18,21-22,24-28,55H2,1-2H3,(H,59,71)(H,63,70)(H,64,72)(H,65,76)(H,66,74)(H,67,77)(H,68,73)(H4,56,57,60)(H,69,75,78)/b41-17+/t35?,36?,38-,40+,42+,43+,44+,45+/m1/s1

SMILES Code

CCCC[C@H](NC(C)=O)C(N[C@H]1CC(NCCC/C=C(NC([C@@H](NC([C@@H](NC([C@H](N)Cc(cc2)cc3c2cccc3)=O)CCCNC(N)=N)=O)CC4CNc5ccccc54)=O)\C(NC([C@H](CC6C=NC=N6)NC1=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.03.00

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.