Ace Therapeutics is a preclinical R&D services company with a particular focus on psychiatric disorders. We are dedicated to providing comprehensive R&D service solutions that will assist our clients in accelerating the process of schizophrenia research and related drug development. Our services encompass all phases of the process, from pathomechanism studies, biomarker discovery and validation, drug screening, efficacy evaluation, to pharmacokinetic and toxicology studies.

Treatment of Schizophrenia

Schizophrenia is usually treated with a combination of individualized talk therapy and medications. Antipsychotics are often recommended as initial treatment for symptoms of acute schizophrenic episodes. These medications reduce the symptoms of schizophrenia, including hallucinations, delusions, and disorganized thinking, primarily by modulating neurotransmitter levels. Antipsychotics can usually reduce anxiety or feelings of aggression within hours of use, but it may take days or weeks to reduce other symptoms, such as hallucinations or delusions.

Major Targets for Anti-schizophrenia Drug Development

• Dopamine D2 receptors
• 5-hydroxytryptamine 2A receptor
• Neurotransmitter glutamate
• Neuropeptide Y (NPY)
• α1-Adrenergic receptors

How Can We Help?

Ace Therapeutics has extensive experience in psychiatry research and antipsychotic drug development. We are committed to helping you develop new anti-psychotic medications that improve efficacy and minimize side effects. We offer many research services including but not limited to:

Pathophysiologic Mechanism Research Services of Schizophrenia

The pathophysiology of schizophrenia involves the function of neurotransmitters in the brain, as well as abnormalities in specific structural and functional features of the brain. Ace Therapeutics employs a multi-disciplinary approach, integrating animal models with our molecular biology and brain imaging technologies, to assist our clients in understanding the complex mechanisms of schizophrenia. Our objective is to provide a solid foundation for early diagnosis of the disease, personalized treatments, and the development of new drugs.

Fig. 1 Network of direct and indirect pathways of basal ganglia involved in motor activity and psychotic symptoms. (Luvsannyam, E., et al., 2022)

Preclinical Screening and Evaluation Services for Anti-Schizophrenia Drugs

Ace Therapeutics has deep experience in psychiatric research and antipsychotic drug development. We are committed to helping you develop new anti-schizophrenic drugs with improved efficacy and reduced side effects. We offer many research services including but not limited to:

• New drug development: In cases where existing anti-schizophrenic drugs do not provide complete relief, we can help you develop new drugs that are more effective, provide faster relief of schizophrenic symptoms, and may reduce side effects.
• Discovering new targets: We can help you find new targets and develop new anti-schizophrenic drugs on those targets to improve the efficacy and safety of your drugs.
• Studying the side effects of drugs: Many anti-schizophrenic drugs are available, but long-term use can cause many side effects, such as diabetes, heart disease, and obesity. We can help you explore ways to mitigate or avoid the side effects of these medications.
• Drug combinations: We can help you study combinations of different kinds of anti-schizophrenic drugs to find the most effective combination regimen.

Diagnostic Method Development Service for Schizophrenia

We assist our clients in the development of accurate and reliable diagnostic tools for schizophrenia through the implementation of a range of methodologies, including biomarker studies, neuroimaging studies, cognitive assessments, and behavioral phenotyping studies. Our interdisciplinary team, state-of-the-art laboratory facilities, and extensive preclinical research and development experience enable us to provide customized research protocols and high-quality data analyses, ensuring that our services meet our clients' needs and contribute to the advancement of schizophrenia research.

Related Services

• Schizophrenia Animal Models
• Behavior Tests in Psychiatry
• Preclinical Imaging Services in Psychiatry
• Cellular Model Development for Schizophrenia
• Toxicological Analysis of Antipsychotics

With Ace Therapeutics' extensive experience in early-stage antipsychotic drug discovery, we have a deep understanding of psychiatric disorders. As a result, we can meet your requirements and provide reliable services. If you are interested in our services, please contact us to learn how we can support you in your project.

Reference

1. Luvsannyam, E.; et al. Neurobiology of schizophrenia: a comprehensive review. Cureus. 14.4 (2022).