Related Diseases
Schizophrenia
Product Name
SB269970 free base
Description
SB269970 is a potent 5-HT7A antagonist (pKi = 8.9) that demonstrates >50-fold binding selectivity over 5-HT5A and >250-fold selectivity over 5-HT1, 5-HT2, 5-HT4, 5-HT6, adrenergic α1, dopamine D2, and dopamine D3 receptors. It is also reported to block adrenergic α2 receptors in guinea pig vas deferens. SB-269970 has been used to target the 5-HT7 receptor in the study of schizophrenia-like cognitive deficits.
CAS Number
201038-74-6 (free base)
Chemical Formula
C18H28N2O3S
Elemental Analysis
C, 61.33; H, 8.01; N, 7.95; O, 13.62; S, 9.10
Synonym
SB2699701; SB-2699701; SB 2699701; SB269970 free base; GR125743; GR-125743; GR 125743;
IUPAC/Chemical Name
3-((2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol
InChi Key
HWKROQUZSKPIKQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3
SMILES Code
OC1=CC(S(N2CCCC2CCN3CCC(C)CC3)(=O)=O)=CC=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).
HS Tariff Code
2934.99.9001