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SB-408124

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Specification

Cat. No.

SMD401

Related Diseases

Anxiety

Product Name

SB-408124

Size

5.0mg; 10.0mg

Price

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Availability

2 Weeks

Description

SB-408124 is a elective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). A critical role for the orexin-1 receptor (OX1R) in complex emotional behavior is emerging, such as overactivation of the OX1R pathway being associated with panic or anxiety states.

CAS Number

288150-92-5 (free base)

Chemical Formula

C19H18F2N4O

Exact Mass

356.1449

Molecular Weight

356.3768

Elemental Analysis

C, 64.04; H, 5.09; F, 10.66; N, 15.72; O, 4.49

Synonym

SB-408124; SB 408124; SB408124 free base

IUPAC/Chemical Name

N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]urea

InChi Key

JTARFZSNUAGHRB-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H18F2N4O/c1-11-8-17(15-9-12(20)10-16(21)18(15)22-11)24-19(26)23-13-4-6-14(7-5-13)25(2)3/h4-10H,1-3H3,(H2,22,23,24,26)

SMILES Code

O=C(NC1=CC=C(N(C)C)C=C1)NC2=CC(C)=NC3=C(F)C=C(F)C=C23

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.