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RU 43044

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Specification

Cat. No.

SMD1165

Related Diseases

Depression

Product Name

RU 43044

Size

Customizable

Price

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Description

RU 43044 is a selective glucocorticoid receptor antagonist that has shown an antidepressant-like effect. Subchronic treatment with RU-43044 decreased the immobility time in the forced swim test in chronic corticosterone-treated and isolation-reared mice, but not the control mice. Chronic corticosterone decreased the levels of cortical glucocorticoid receptors and stress-induced increases in plasma corticosterone levels, and blocked the response of plasma corticosterone to dexamethasone, while isolation rearing did not cause any changes in the glucocorticoid receptor system. Subchronic RU-43044 reversed the enhanced release of dopamine in the prefrontal cortex of chronic corticosterone-treated and isolation-reared mice.

CAS Number

136959-96-1

Chemical Formula

C29H34O2

Exact Mass

414.2559

Molecular Weight

414.58

Elemental Analysis

C, 84.02; H, 8.27; O, 7.72

Synonym

RU 43044; RU-43044; RU43044; RU-044; RU044; RU-044;

IUPAC/Chemical Name

(8S,10R,13S,14R,17R)-17-hydroxy-13-methyl-10-(4-methylbenzyl)-17-(prop-1-yn-1-yl)-1,2,6,7,8,10,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

InChi Key

NSUUUQRFPXZFLI-OWWDREAESA-N

InChi Code

InChI=1S/C29H34O2/c1-4-14-29(31)17-13-25-24-10-9-22-18-23(30)11-16-28(22,26(24)12-15-27(25,29)3)19-21-7-5-20(2)6-8-21/h5-8,12,18,24-25,31H,9-11,13,15-17,19H2,1-3H3/t24-,25+,27-,28+,29+/m0/s1

SMILES Code

O=C1CC[C@]2(CC3=CC=C(C)C=C3)C4=CC[C@]5(C)[C@](C#CC)(O)CC[C@]5([H])[C@]4([H])CCC2=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.