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Rosonabant

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Specification

Cat. No.

SMD362

Related Diseases

Anxiety

Product Name

Rosonabant

Size

Customizable

Price

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Description

Rosonabant aslo known as E-6776, is a CB1 receptor antagonist/inverse agonist that was under investigation by Esteve as an appetite suppressant for the treatment of obesity. Development of the drug for clinical use was apparently halted shortly after the related CB1 antagonist rimonabant was discontinued, likely due to the reports of severe psychiatric adverse effects such as anxiety, depression, and suicidal ideation associated with it and with similarly-acting agents.

CAS Number

861151-12-4

Chemical Formula

C21H21Cl3N4O

Exact Mass

450.0781

Molecular Weight

451.776

Elemental Analysis

C, 55.83; H, 4.69; Cl, 23.54; N, 12.40; O, 3.54

Synonym

E-6776; E 6776; E6776; Rosonabant

IUPAC/Chemical Name

(R)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4,5-dihydro-1H-pyrazole-3-carboxamide

InChi Key

WMMMJGKFKKBRQR-HXUWFJFHSA-N

InChi Code

InChI=1S/C21H21Cl3N4O/c22-15-6-4-14(5-7-15)20-13-18(21(29)26-27-10-2-1-3-11-27)25-28(20)19-9-8-16(23)12-17(19)24/h4-9,12,20H,1-3,10-11,13H2,(H,26,29)/t20-/m1/s1

SMILES Code

O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)[C@@H](C3=CC=C(Cl)C=C3)C1)NN4CCCCC4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.