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RO5263397 HCl

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Specification

Cat. No.

SMD1707

Related Diseases

Schizophrenia

Related Diseases

Depression

Product Name

RO5263397 HCl

Size

Customizable

Price

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Description

RO5263397 is a selective TAAR 1 agonist. RO5263397 was efficacious in reducing cocaine-mediated behaviors. RO5263397 dose-dependently prevented cocaine-induced lowering of ICSS thresholds. TAAR1 stimulation effectively suppresses the rewarding and reinforcing effects of cocaine in self-administration and ICSS models, supporting the candidacy of TAAR1 as a drug discovery target for cocaine addiction.

CAS Number

1357266-05-7 (free base)

Chemical Formula

C10H13Cl2FN2O

Molecular Weight

267.1254

Elemental Analysis

C, 44.96; H, 4.91; Cl, 26.54; F, 7.11; N, 10.49; O, 5.99

Synonym

RO5263397; RO-5263397; RO 5263397.

IUPAC/Chemical Name

(S)-4-(3-fluoro-2-methylphenyl)-4,5-dihydrooxazol-2-amine dihydrochloride

InChi Key

GZJSFLYZAYEEKB-KLQYNRQASA-N

InChi Code

InChI=1S/C10H11FN2O.2ClH/c1-6-7(3-2-4-8(6)11)9-5-14-10(12)13-9;;/h2-4,9H,5H2,1H3,(H2,12,13);2*1H/t9-;;/m1../s1

SMILES Code

NC1=N[C@@H](C2=C(C)C(F)=CC=C2)CO1.[H]Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.