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RO5256390 HCl

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Specification

Cat. No.

SMD1684

Related Diseases

Schizophrenia

Related Diseases

Depression

Product Name

RO5256390 HCl

Size

Customizable

Price

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Description

RO5256390 is a TAAR1 agonist. RO5256390 blocks psychostimulant-induced hyperactivity and produces a brain activation pattern reminiscent of the antipsychotic drug olanzapine, suggesting antipsychotic-like properties. TAAR1 activation promotes vigilance in rats and shows pro-cognitive and antidepressant-like properties in rodent and primate models. TAAR1 agonists may provide a novel and differentiated treatment of schizophrenia as compared with current medication standards: TAAR1 agonists may improve not only the positive symptoms but also the negative symptoms and cognitive deficits, without causing adverse effects such as motor impairments or weight gain.

CAS Number

1043495-96-0 (free base)

Chemical Formula

C13H20Cl2N2O

Molecular Weight

291.216

Elemental Analysis

C, 53.62; H, 6.92; Cl, 24.35; N, 9.62; O, 5.49

Synonym

RO5256390; RO-5256390; RO 5256390.

IUPAC/Chemical Name

(S)-4-((S)-2-phenylbutyl)-4,5-dihydrooxazol-2-amine dihydrochloride

InChi Key

NCOOUUDYVQYIDE-HFXMYSAISA-N

InChi Code

InChI=1S/C13H18N2O.2ClH/c1-2-10(11-6-4-3-5-7-11)8-12-9-16-13(14)15-12;;/h3-7,10,12H,2,8-9H2,1H3,(H2,14,15);2*1H/t10-,12-;;/m0../s1

SMILES Code

NC1=N[C@@H](C[C@@H](C2=CC=CC=C2)CC)CO1.[H]Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.