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RO5203648 HCl

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Specification

Cat. No.

SMD1149

Related Diseases

Depression

Product Name

RO5203648 HCl

Size

Customizable

Price

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Description

RO5203648 is a TAAR1 partial agonist (Trace amine-associated receptor 1). RO5203648 showed high affinity and potency at TAAR1, high selectivity versus other targets, and favorable pharmacokinetic properties. RO5203648 increased the firing frequency of dopaminergic and serotonergic neurons in the ventral tegmental area and the dorsal raphe nucleus, respectively. RO5203648 demonstrated clear antipsychotic- and antidepressant-like activities as well as potential anxiolytic-like properties.

CAS Number

1043491-54-8 (free base)

Chemical Formula

C9H10Cl4N2O

Molecular Weight

303.992

Elemental Analysis

C, 35.56; H, 3.32; Cl, 46.65; N, 9.22; O, 5.26

Synonym

RO5203648; RO-5203648; RO 5203648.

IUPAC/Chemical Name

(S)-4-(3,4-dichlorophenyl)-4,5-dihydrooxazol-2-amine dihydrochloride

InChi Key

ZYORSKYGFHCZDA-YCBDHFTFSA-N

InChi Code

InChI=1S/C9H8Cl2N2O.2ClH/c10-6-2-1-5(3-7(6)11)8-4-14-9(12)13-8;;/h1-3,8H,4H2,(H2,12,13);2*1H/t8-;;/m1../s1

SMILES Code

NC1=N[C@@H](C2=CC=C(Cl)C(Cl)=C2)CO1.[H]Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.