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RO27-3225 TFA

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Specification

Cat. No.

SMD350

Related Diseases

Anxiety

Product Name

RO27-3225 TFA

Size

Customizable

Price

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Description

RO27-3225, also known as RO273225 is a melanocortin type 4 receptor agonist with EC50 = 1 nM. It may alleviate intestinal dysfuntion and brain damage. It has been investigated for an anti-obesity medication. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival.

CAS Number

1373926-49-8 (TFA)

Chemical Formula

C41H53F3N12O8

Molecular Weight

898.9462

Elemental Analysis

C, 54.78; H, 5.94; F, 6.34; N, 18.70; O, 14.24

Synonym

RO27-3225 TFA; RO273225; RO 273225; RO-273225; RO27-3225; RO27 3225; Butir-His-D-Phe-Arg-Trp-Sar-NH2; CID 9962372;

IUPAC/Chemical Name

(S)-N-((S)-1-((2-amino-2-oxoethyl)(methyl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-2-((S)-2-((S)-2-butyramido-3-(1H-imidazol-4-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide trifluoroacetic acid

InChi Key

XBNXUPIBUGBMCO-WYDLTDSDSA-N

InChi Code

InChI=1S/C39H52N12O6.C2HF3O2/c1-3-10-34(53)47-31(19-26-21-43-23-46-26)37(56)49-30(17-24-11-5-4-6-12-24)36(55)48-29(15-9-16-44-39(41)42)35(54)50-32(38(57)51(2)22-33(40)52)18-25-20-45-28-14-8-7-13-27(25)28;3-2(4,5)1(6)7/h4-8,11-14,20-21,23,29-32,45H,3,9-10,15-19,22H2,1-2H3,(H2,40,52)(H,43,46)(H,47,53)(H,48,55)(H,49,56)(H,50,54)(H4,41,42,44);(H,6,7)/t29-,30-,31-,32-;/m0./s1

SMILES Code

O=C(O)C(F)(F)F.O=C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N(CC(N)=O)C)=O)[C@@H](NC([C@@H](NC([C@@H](NC(CCC)=O)CC3=CNC=N3)=O)CC4=CC=CC=C4)=O)CCCNC(N)=N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.