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RO-5328673

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Specification

Cat. No.

SMD1691

Related Diseases

Schizophrenia

Product Name

RO-5328673

Size

Customizable

Price

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Description

RO-5328673 is a dual NK2/NK3 antagonist. O5328673. [(3)H]RO5328673 bound to a single saturable site on hNK2, hNK3 and gpNK3 with high-affinity. RO5328673 acted as an insurmountable antagonist at both human and guinea-pig NK3 receptors in the [(3)H]IP accumulation assay. In binding kinetic analyses, [(3)H]RO5328673 had fast association and dissociation rates at hNK2 while it had a fast association rate and a remarkably slow dissociation rate at gp and hNK3. In electrophysiological recordings of gp SNpc, RO5328673 inhibited the senktide-induced potentiation of spontaneous activity of dopaminergic neurons with an insurmountable mechanism of action. RO5328673 exhibited in-vivo activity in gerbils, robustly reversing the senktide-induced locomotor activity.

CAS Number

1310817-94-7

Chemical Formula

C29H32Cl2FN3O4

Exact Mass

575.1754

Molecular Weight

576.4904

Elemental Analysis

C, 60.42; H, 5.60; Cl, 12.30; F, 3.30; N, 7.29; O, 11.10

Synonym

RO-5328673; RO 5328673; RO5328673;

IUPAC/Chemical Name

4-Fluorophenyl N-[(3S,4R)-4-(3,4-dichlorophenyl)-1-[[1-[(1-methylcyclopropyl)carbonyl]-4-piperidinyl]carbonyl]-3-pyrrolidinyl]-N-methylcarbamate

InChi Key

QQHBMXDSZDWXLY-WIOPSUGQSA-N

InChi Code

InChI=1S/C29H32Cl2FN3O4/c1-29(11-12-29)27(37)34-13-9-18(10-14-34)26(36)35-16-22(19-3-8-23(30)24(31)15-19)25(17-35)33(2)28(38)39-21-6-4-20(32)5-7-21/h3-8,15,18,22,25H,9-14,16-17H2,1-2H3/t22-,25+/m0/s1

SMILES Code

O=C(OC1=CC=C(F)C=C1)N([C@@H]2CN(C(C3CCN(C(C4(C)CC4)=O)CC3)=O)C[C@H]2C5=CC=C(Cl)C(Cl)=C5)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.