Related Diseases
Schizophrenia
Description
Reserpine is an alkaloid vesicular monoamine transporter 2 (VMAT2) inhibitor, that inhibits the uptake of norepinephrine into storage vesicles, resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. Reserpine has been used as an antihypertensive and an antipsychotic.
CAS Number
50-55-5 (free)
Chemical Formula
C33H40N2O9
Elemental Analysis
C, 65.12; H, 6.62; N, 4.60; O, 23.66
Synonym
Reserpine, Reserpine phosphate, Raudixin, Serpalan, Serpasil
IUPAC/Chemical Name
methyl (1S,2R,3R,4aS,13bR,14aS)-2,11-dimethoxy-3-((3,4,5-trimethoxybenzoyl)oxy)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate
InChi Key
QEVHRUUCFGRFIF-MDEJGZGSSA-N
InChi Code
InChI=1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
SMILES Code
CO[C@H]1[C@H](OC(C2=CC(OC)=C(OC)C(OC)=C2)=O)C[C@@H]3CN4CCC5=C([C@H]4C[C@@H]3[C@@H]1C(OC)=O)NC6=CC(OC)=CC=C56
Appearance
White to light yellow crystalline powder.
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).
HS Tariff Code
2934.99.9001