Ace Therapeutics is dedicated to helping researchers and professionals understand the biology associated with mental illness, explore new therapies and strategies for mental illness, and develop new biomarkers for mental illness. We now offer high-quality reactive oxygen species (ROS) assays to support basic and translational psychiatric disease research projects. Based on an advanced platform and years of research experience in the field of psychiatric disorders, we are committed to providing our clients with the customized services to meet the specific needs of their projects.

Introduction of Reactive Oxygen Species (ROS) Assays in Psychiatry

Recently, there is growing evidence that oxidative stress is involved in the development of psychiatric disorders because the brain is vulnerable to oxidative stress due to its structure (i.e., lipid-rich) and function (i.e., high oxygen consumption, moderate antioxidant systems, presence of reducing agents such as iron and copper, and reduced capacity of neurotransmitters). When reactive oxygen species (ROS) such as superoxide radicals, hydroxyl radicals, and hydrogen peroxide (H₂O₂ ) are produced in excess, an imbalance in the oxidative and antioxidant systems occurs. As a result, oxidative stress occurs, leading to damage to cells, lipids, deoxyribonucleic acid (DNA) or other components.

Fig. 1 Role of imbalanced ROS production in psychiatric disorders. (Raza MU, et al., 2016)

ROS Assay Services

Ace Therapeutics offers two general assays for the detection of reactive oxygen species: an intracellular ROS assay for intact cells and an in vitro ROS assay for cell lysates, tissue homogenates, blood or urine. In addition, we offer specific quantitative assays for hydrogen peroxide and nitric oxide. Not only can we provide sample-specific ROS assays, but we can also use our technology platform to help you analyze the role of ROS and oxidative damage in the pathophysiology of schizophrenia. As a result, our services can greatly enhance our clients' understanding of the pathology of psychiatric disorders.

Sample Request

• Intracellular ROS assay: intact cultured cells
• In vitro ROS/RNS assay: tissue sections, plasma, serum, urine, cell lysates or cell culture supernatants
• Hydrogen peroxide assay: cell lysates, tissue homogenates, cell culture supernatants, plasma, serum, urine, or other biological fluids
• Intracellular nitric oxide assay: intact cultured cells
• In vitro nitric oxide assay: cell lysates, tissue homogenates, plasma, serum, saliva, urine, and cell culture supernatants

What Can We Help You Achieve in Psychiatry?

• Investigating the role of reactive oxygen species-mediated damage in the pathogenesis of schizophrenia
• Elucidating the role of antioxidants in the pathogenesis of schizophrenia
• Investigating the role of mitochondrial dysfunction in schizophrenia
• Investigating the mechanisms of antioxidant defense imbalance in psychiatric disorders
• Developing antioxidant therapies for schizophrenia
• Studying the mechanism of antioxidant action of antipsychotic drugs
• Studying the role of ROS in the development of certain cancer-related depressions
• Study of the inflammatory mitochondrial response in major depressive disorder
• Development of biomarkers for psychiatric disorders

Ace Therapeutics is committed to helping you study the role of ROS and oxidative damage in the pathophysiology of schizophrenia through oxidative stress testing. Thank you for your interest in our services. If you are interested in our services, please make an inquiry and let us know what you would like to achieve and our team of experts will contact you within one business day to discuss your needs.

Reference

1. Raza MU, et al. DNA Damage in Major Psychiatric Diseases. Neurotox Res. 2016, 30(2):251-267.