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Raseglurant

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Specification

Cat. No.

SMD338

Related Diseases

Anxiety

Product Name

Raseglurant

Size

Customizable

Price

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Description

Raseglurant (INN) (code name ADX-10059) is a negative allosteric modulator of the mGlu5 receptor and derivative of MPEP which was under development by Addex Therapeutics for the treatment of migraine, gastroesophageal reflux disease, and dental anxiety. It reached phase II clinical trials for all of the aforementioned indications before being discontinued due to the observation of possible predictive signs of hepato toxicity in patients with long-term use.

CAS Number

757950-09-7

Chemical Formula

C15H13FN2

Exact Mass

240.1063

Molecular Weight

240.2814

Elemental Analysis

C, 74.98; H, 5.45; F, 7.91; N, 11.66

Synonym

Raseglurant

IUPAC/Chemical Name

2-[2-(3-Fluorophenyl)ethynyl]-4,6-dimethylpyridin-3-amine

InChi Key

MEDCLNYIYBERKO-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H13FN2/c1-10-8-11(2)18-14(15(10)17)7-6-12-4-3-5-13(16)9-12/h3-5,8-9H,17H2,1-2H3

SMILES Code

NC1=C(C)C=C(C)N=C1C#CC2=CC=CC(F)=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.