Ace Therapeutics focuses on all available biochemical methods and advanced biophysical techniques for identifying relevant protein molecules and dissecting the function of cellular protein-protein interactions (PPI) under well-defined conditions. We are committed to helping you understand the mechanisms of signal transduction, transmembrane transport, cellular metabolism, and biological processes related to protein interactions in psychopathology.

Introduction of Protein-protein Interaction (PPI) Analysis in Psychiatry

Cellular biomolecular complexes, including protein-protein, protein-RNA and protein-DNA interactions, regulate and perform most biological functions. In particular, in the brain, PPIs mediate or regulate almost all neuronal functions, such as neurotransmission, intercellular communication, neurogenesis, synaptogenesis and synaptic plasticity. It has been reported that some researchers have identified several previously unidentified disease marker genes and drug targets based on statistical and topological analysis of PPI networks, such as SBNO2 (schizophrenia), SEC24C (bipolar disorder) and SRRT (major depressive disorder). Thus, studying protein-protein interactions could bring new insights into the network biology of psychiatric disorders and help us understand the interrelationships between disease-associated genes and proteins.

Fig. 1 The PPI network associated with heroin use disorder. (Chen SJ, et al., 2019)

Protein-protein Interaction (PPI) Analysis Services

Ace Therapeutics provides relevant PPI analysis services to those involved in psychiatric research. With over 10 years of experience in the field of anti-psychiatric drug development, we are ready to provide our clients with exceptional service. We use various techniques to study PPI, such as

Ace Therapeutics can even provide advanced data mining services such as

• Prediction of protein-interaction sites
• Reliability assessment of protein-protein interactions
• Creation of interaction networks for specific sets of proteins and involvement in pathological/physiological processes

What Can We Help You Achieve in Psychiatry with PPI Analysis?

• Understand how genetic mutations lead to the rewiring of protein interaction networks that lead to the development of psychiatric disorders.
• Identify proteomes in different cell types in the brain as well as proteomes and PPIs in difficult-to-separate structures such as synaptic gaps, axonal projections, or astrocyte-neuron connections
• Study the molecular mechanisms of psychiatric disorders
• Identify genes critical for effective antidepressant drug targeting
• Study synaptic pathology related to cognition

Our Advantages

• Significantly reduced false alarm rate
• Short turnaround time
• Highly customizable service
• Flexible quotations adapted to your requirements
• High-value scientific assistance

Ace Therapeutics welcomes projects of any size and our scientists will be happy to help you determine the best solution for your project, please feel free to make an inquiry.

Reference

1. Chen SJ, et al. Construction and Analysis of Protein-Protein Interaction Network of Heroin Use Disorder. Sci Rep. 2019, 9(1):4980.