Non-invasive brain stimulation techniques have emerged as promising interventions for these disorders, offering potential therapeutic benefits with minimal side effects. Ace Therapeutics is a preclinical contract research organization focused on developing innovative therapies for psychiatric disorders. We are dedicated to utilizing our expertise and platform technologies to provide comprehensive support to our clients in the development and improvement of non-invasive brain stimulation techniques. Our goal is to facilitate the continued development of innovative therapies in the field and personalized treatment of disorders.

Fig. 1 Brain-stimulation techniques and mechanism of action. (Scangos, K. W. et al., 2023)

Introduction of Non-Invasive Brain Stimulation (NIBS)

Non-invasive brain stimulation techniques, such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and transcranial alternating current stimulation (tACS), have become powerful treatment options for a range of mental and neurological disorders. These techniques offer non-surgical and well-tolerated methods of neuromodulation that effectively modulate brain activity, relieve symptoms, and enhance cognitive function. They provide potential therapeutic benefits for patients with neuropsychiatric disorders, including major depressive disorder, Parkinson's disease, schizophrenia, insomnia, and cognitive impairments.

What Can We Offer in Non-Invasive Brain Stimulation Therapy Development?

• Neurobiological mechanisms neurobiological mechanisms of psychiatric disorders

The future of NIBS therapies relies on identifying new targets and brain regions for different psychiatric disorders, aiming for more targeted and precise treatments. Ace Therapeutics provides a better understanding of the neurobiological changes induced by NIBS by exploring the neurobiological mechanisms of psychiatric disorders and their modulation through non-invasive brain stimulation.

We use neuroimaging techniques such as electroencephalography (EEG), functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and single-photon emission computed tomography (SPECT) in combination with NIBS to discover biomarkers of neuropsychiatric disorders. This approach offers a more detailed view of brain networks, aiding in the comprehension of the therapeutic mechanisms of NIBS and facilitating the development of more accurate and personalized treatment plans for psychiatric disorders.

• Preclinical development services of NIBS therapies

In the preclinical development of NIBS therapies, our research focuses on improving therapy precision and effectiveness. Technological and methodological improvements can demonstrate greater specificity in treating specific psychiatric disorders.

• Our experts design and conduct rigorous preclinical efficacy studies to evaluate the safety and effectiveness of NIBS therapies for psychiatric disorders.
• We utilize validated animal models to determine optimal treatment parameters, frequency, duration, and current intensity.
• Our findings and analytical reports will provide valuable data and insights for the clinical development of innovative NIBS therapies.
• Combination therapy development and evaluation services

NIBS techniques, alongside pharmacotherapy and psychotherapy, have emerged as a valuable management option for neuropsychiatric disorders. Our team creates personalized combination therapies tailored to our clients' needs. We conduct thorough preclinical efficacy and safety evaluations of these therapies in animal models. Additionally, we optimize key therapeutic parameters based on the results of these evaluations and define treatment timeframes to guide best practices and ensure therapeutic efficacy in the clinical application of combination therapies.

Advantages of Our NIBS Development Services

• An experienced team of experts provides customized NIBS therapy development strategies and incorporates the latest technologies and methodologies in the development process.
• Cutting-edge neuroimaging and electrophysiological techniques can help to fully understand the underlying biological mechanisms of psychiatric disorders and the potential applications of NIBS technology in neuropsychiatric disorders.
• Comprehensive data analysis and assay reports enable clients to make informed decisions about the further development and potential translation of NIBS therapies.

By partnering with Ace Therapeutics, you can leverage our expertise in psychiatry and non-invasive brain stimulation therapy development to accelerate the progress of your psychiatric treatment program. Contact us today to learn more about how our expertise and services can support your NIBS therapy development.

References

1. Scangos, K. W.; et al. New and emerging approaches to treat psychiatric disorders. Nature medicine. 29.2 (2023): 317-333.
2. Aderinto, N.; et al. A narrative review of non-invasive brain stimulation techniques in neuropsychiatric disorders: current applications and future directions. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery. 60.1 (2024): 50.
3. Cocchi, L.; et al. Personalized transcranial magnetic stimulation in psychiatry. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 3.9 (2018): 731-741.