Based on the assumption that an adequate supply of oxygen may benefit physical functions, hyperbaric oxygen therapy (HBOT) has been considered an adjunctive candidate therapy in many disorders via increasing the amount of oxygen dissolved in the blood. In recent years, this non-pharmacological therapy has taken a further step to show its effectiveness in preventing neuronal damage and activating the functions of several brain areas, thus extending its utility in treating psychiatric disorders. Ace Therapeutics is a preclinical contract research organization that specializes in developing therapies for psychiatric disorders. Our experienced researchers and scientists provide professional services and comprehensive support to accelerate the progress of your program in the field of psychiatric treatment. We work closely with you to develop innovative hyperbaric oxygen therapies.

Fig. 1 HBOT improves brain function. (Gottfried, I. et al., 2021)

Introduction of Hyperbaric Oxygen Therapy

In hyperbaric oxygen therapy (HBOT), subjects are placed in a chamber containing 100% oxygen at a pressure exceeding one absolute atmosphere. This therapy is used to accelerate tissue recovery and improve the physiological aspects of damaged tissues by increasing their oxygen supply.

Studies have shown that HBOT causes molecular changes in the central nervous system (CNS) of subjects afflicted with neurological conditions, including changes in mitochondrial function, white matter, neuroinflammation, oxidative stress, and CBF. HBOT improves various aspects of brain activity, including cerebral blood flow, metabolism, and microstructure, resulting in enhanced cognitive and physical function, sleep, and gait, leading to improved overall performance.

Although several research progress has been made, broader clinical applications of HBOT in psychiatric disorders require more basic research and preclinical trials to reveal additional mechanisms of HBOT action and to assess the efficacy and safety of HBOT for specific psychiatric disorders.

Fig. 2 Key molecular changes in the brain following hyperbaric oxygen therapy (HBOT). (Fischer, I. et al., 2020)

What Can We Offer in Hyperbaric Oxygen Therapy Development?

• Neurobiological mechanisms research services of HBOT

To develop more effective HBOT therapies, our scientific team investigates the neurobiological mechanisms of psychiatric disorders and how HBOT can potentially modulate them.

We will focus on providing customised research strategies to our clients in the following areas:

• Explore the deep mechanisms underlying the interactions between myelination processes, mitochondrial activity, angiogenesis, and molecular changes such as neuroinflammation in the context of HBOT.
• We also examine the connection between the molecular mechanisms and therapeutic aspects. For example, animal models are used to explore associations between brain regions that undergo molecular changes and behavioral effects on subject animals.

Our preclinical mechanistic studies and comprehensive data analysis can help elucidate the specific neurobiological changes and therapeutic targets affected by HBOT. This information can be used to identify potential therapeutic targets and develop innovative modes of action for HBOT.

• Preclinical HBOT therapy development services

• Our experts will work with you to develop and deliver customized preclinical HBOT efficacy and safety assessment protocols.
• We use validated animal models and behavioral tests to help you evaluate the efficacy of HBOT for different psychiatric disorders.
• Our experienced specialists incorporate factors such as oxygen pressure, dosing regimen, treatment duration, and relevant outcome measures to develop robust study protocols that align with our client's treatment objectives and provide comprehensive data analysis reports.

These results provide valuable insights and guidance for further optimization and development of HBOT therapy.

• Combination therapy development and evaluation services

As part of our integrative therapy development, we assist clients in identifying and screening promising drug combination therapies. We then develop customized therapeutic combinations based on the mechanism of action of different psychiatric disorders and HBOT therapies. We use validated animal models to comprehensively evaluate and optimize the efficacy and safety of combination therapies, ensuring better treatment outcomes.

Advantages of Our HBOT Development Services

• Our team of experienced experts offers customized development services for HBOT therapy to help you successfully create innovative therapies.
• A wide range of molecular biology techniques, histological methods, neurophysiological measures, and behavioral analyses ensure the ability to design and conduct comprehensive studies for HBOT development.
• Comprehensive data analysis reports provide data support and guidance for further development of HBOT.

Ace Therapeutics is dedicated to providing scientific expertise, program management support, and strategic guidance to ensure the success of your HBOT therapeutic development and its effectiveness in treating psychiatric disorders. Contact us today to learn more about how we can help you develop innovative HBOT therapies for psychiatric disorders.

References

1. Fischer, I.; et al. Molecular and therapeutic aspects of hyperbaric oxygen therapy in neurological conditions. Biomolecules. 10.9 (2020): 1247.
2. Gottfried, I.; et al. Hyperbaric oxygen treatment-from mechanisms to cognitive improvement. Biomolecules. 11.10 (2021): 1520.
3. Lin, C. C.; et al. Hyperbaric oxygen therapy restored traumatic stress-induced dysregulation of fear memory and related neurochemical abnormalities. Behavioural brain research. 359 (2019): 861-870.