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Pomaglumetad methionil free base

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Specification

Cat. No.

SMD1667

Related Diseases

Schizophrenia

Product Name

Pomaglumetad methionil free base

Size

Customizable

Price

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Description

Pomaglumetad methionil, also known as LY2140023, is a prodrug of LY-404039 and a a novel metabotropic glutamate 2/3 receptor agonist peptide prodrug. Pomaglumetad methionil is currently in clinical development as a potential new treatment for schizophrenia. LY2140023 is generally well tolerated and appears to have a low association with adverse events related to dopamine D2 receptor antagonism and with weight gain, which are commonly seen with current antipsychotics.

CAS Number

635318-55-7 (free base)

Chemical Formula

C12H18N2O7S2

Exact Mass

366.055

Molecular Weight

366.403

Elemental Analysis

C, 39.34; H, 4.95; N, 7.65; O, 30.57; S, 17.50

Synonym

LY2140023; LY-2140023; LY 2140023; LY2140023 monohydrate; Prodrug of LY-404039; Pomaglumetad methionil

IUPAC/Chemical Name

(1R,4S,5S,6S)-4-((S)-2-amino-4-(methylthio)butanamido)-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide

InChi Key

VOYCNOJFAJAILW-CAMHOICYSA-N

InChi Code

InChI=1S/C12H18N2O7S2/c1-22-3-2-5(13)9(15)14-12(11(18)19)4-23(20,21)8-6(7(8)12)10(16)17/h5-8H,2-4,13H2,1H3,(H,14,15)(H,16,17)(H,18,19)/t5-,6+,7+,8-,12-/m0/s1

SMILES Code

O=C([C@]1(NC([C@@H](N)CCSC)=O)CS([C@@]2([H])[C@H](C(O)=O)[C@@]12[H])(=O)=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.