Inquiry

* Name

Phone

* Email

* Services or Products of Interest

Project Description

* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

* Tick to confirm the Research Use Only (RUO) statement.

PNU-101017

Inquiry

Specification

Cat. No.

SMD372

Related Diseases

Anxiety

Product Name

PNU-101017

Size

Customizable

Price

Inquiry

Description

PNU-101017, also known as U-101017, is a gamma-aminobutyric acid (GABA) receptor agonist potentially for the treatment of anxiety. PNU-101017 has a high affinity for the GABAA receptor subtypes containing the alpha 1 and alpha 3 or alpha 5 subunits. PNU-101017 was weakly active in anti-conflict anxiolytic tests, but attenuated the plasma corticosteroid response to mild stress in rats. PNU-101017 did not potentiate the CNS-depressant effects of ethanol, and produced no evidence of physical dependence when administered repeatedly.

CAS Number

170568-47-5

Chemical Formula

C23H27ClN4O3

Exact Mass

442.1772

Molecular Weight

442.944

Elemental Analysis

C, 62.37; H, 6.14; Cl, 8.00; N, 12.65; O, 10.84

Synonym

PNU-101017; PNU101017; PNU 101017; U-101017; U 101017; U101017

IUPAC/Chemical Name

tert-butyl 7-chloro-5-((3R,5S)-3,5-dimethylpiperazine-1-carbonyl)imidazo[1,5-a]quinoline-3-carboxylate

InChi Key

JOJRKTAQXYPHBT-OKILXGFUSA-N

InChi Code

InChI=1S/C23H27ClN4O3/c1-13-10-27(11-14(2)26-13)21(29)17-9-19-20(22(30)31-23(3,4)5)25-12-28(19)18-7-6-15(24)8-16(17)18/h6-9,12-14,26H,10-11H2,1-5H3/t13-,14+

SMILES Code

O=C(C1=C2N(C=N1)C3=C(C=C(Cl)C=C3)C(C(N4C[C@@H](C)N[C@@H](C)C4)=O)=C2)OC(C)(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.