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PF-06767832

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Specification

Cat. No.

SMD1651

Related Diseases

Schizophrenia

Product Name

PF-06767832

Size

5.0mg; 10.0mg; 25.0mg

Price

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Availability

2 Weeks

Description

PF-06767832 is a high quality M1 selective PAM (M1 PAM EC50 = 60 nM; M2-M5 PAM EC50 > 10 microM; CNS MPO = 4.9). PF-06767832 has well aligned physicochemical properties, good brain penetration and pharmacokinetic properties. Extensive safety profiling suggested that despite being devoid of mAChR M2/M3 subtype activity, compound 38 still carries gastrointestinal and cardiovascular side effects. These data provide strong evidence that M1 activation contributes to the cholinergic liabilities that were previously attributed to activation of the M2 and M3 receptors.

CAS Number

1859081-58-5

Chemical Formula

C22H23N3O3S

Exact Mass

409.146

Molecular Weight

409.504

Elemental Analysis

C, 64.53; H, 5.66; N, 10.26; O, 11.72; S, 7.83

Synonym

PF-06767832; PF 06767832; PF06767832; PF-6767832; PF 6767832; PF6767832

IUPAC/Chemical Name

N-((3R,4S)-3-hydroxytetrahydro-2H-pyran-4-yl)-5-methyl-4-(4-(thiazol-4-yl)benzyl)picolinamide

InChi Key

VVZZHFMLRHJXTO-RXVVDRJESA-N

InChi Code

InChI=1S/C22H23N3O3S/c1-14-10-23-19(22(27)25-18-6-7-28-11-21(18)26)9-17(14)8-15-2-4-16(5-3-15)20-12-29-13-24-20/h2-5,9-10,12-13,18,21,26H,6-8,11H2,1H3,(H,25,27)/t18-,21-/m0/s1

SMILES Code

O=C(C1=NC=C(C)C(CC2=CC=C(C3=CSC=N3)C=C2)=C1)N[C@@H]4[C@@H](O)COCC4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.