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PF-06256142

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Specification

Cat. No.

SMD1656

Related Diseases

Schizophrenia

Product Name

PF-06256142

Size

Customizable

Price

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Description

PF-06256142 is a potent and selective orthosteric agonist of the D1 receptor with D1 EC50=30 nM and D1 binding Ki = 12 nM. PF-06256142 may be useful for treatment of Parkinson’s disease (PD) and schizophrenia. PF-06256142 has reduced receptor desensitization relative to dopamine and other catechol-containing agonists. PF-06256142 has the (+)-Enantiomer with [α]20/D = +35.2 (c 0.32, CH2Cl2). The pharmacokinetic properties of PF-06256142 such as metabolic stability, high passive permeability, and low MDR and BCRP efflux ratios make this compound suitable for oral dosing and in vivo study.

CAS Number

1609583-14-3 (rotation +)

Chemical Formula

C21H16N4O2

Exact Mass

356.1273

Molecular Weight

356.385

Elemental Analysis

C, 70.77; H, 4.53; N, 15.72; O, 8.98

Synonym

PF-06256142; PF 06256142; PF06256142;

IUPAC/Chemical Name

(+)-4-(3-Methyl-4-(6-methylimidazo[1,2-a]pyrazin-5-yl)phenoxy)furo[3,2-c]-pyridine

InChi Key

HWAIAGZSWHOLLK-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H16N4O2/c1-13-11-15(27-21-17-6-10-26-18(17)5-7-23-21)3-4-16(13)20-14(2)24-12-19-22-8-9-25(19)20/h3-12H,1-2H3

SMILES Code

CC1=CC(OC2=NC=CC3=C2C=CO3)=CC=C1C4=C(N=CC5=NC=CN45)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.03.00

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.