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PF-04859989

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Specification

Cat. No.

SMD1658

Related Diseases

Schizophrenia

Product Name

PF-04859989

Size

Customizable

Price

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Description

PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II). PF-04859989 has IC50 values of 23 nM for hKAT II and 263 nM for rKAT II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV.

CAS Number

34783-48-7 (free base)

Chemical Formula

C9H10N2O2

Exact Mass

178.0742

Molecular Weight

178.19

Elemental Analysis

C, 60.66; H, 5.66; N, 15.72; O, 17.96

Synonym

PF-04859989; PF 04859989; PF04859989;

IUPAC/Chemical Name

(S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one

InChi Key

HYTRYTZFJVVZAF-ZETCQYMHSA-N

InChi Code

InChI=1S/C9H10N2O2/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12/h1-4,7,13H,5,10H2/t7-/m0/s1

SMILES Code

ON(C1=CC=CC=C1C[C@@H]2N)C2=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.