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PD 142505-0028

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Specification

Cat. No.

SMD520

Related Diseases

Autism

Product Name

PD 142505-0028

Size

Customizable

Price

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Description

PD 142505-0028 (or CI-1017) is a functionally M1-selective muscarinic agonist. It rapidly increases glutamate but not aspartate concentrations in the striatum of anesthetized rats. improved spatial memory of hippocampally deficient mice and nbM-lesioned rats at doses of 1.0-3.2 and 0.1-0.3 mg/kg, respectively, while producing parasympathetic side effects only at very high doses (100-178 mg/kg). Additionally, CI-1017 inhibited production of amyloidogenic A beta and increased secretion of soluble APP. Thus, CI-1017, besides treating AD symptomatically, may also retard its progression.

CAS Number

161774-09-0

Chemical Formula

C18H20N2O6

Exact Mass

360.1321

Molecular Weight

360.3612

Elemental Analysis

C, 59.99; H, 5.59; N, 7.77; O, 26.64

Synonym

CI-1017; CI1017; CI 1017; PD-142505-0028; PD42505-0028; PD 142505-0028

IUPAC/Chemical Name

(E)-1-azabicyclo[2.2.1]heptan-3-one O-(3-(3-methoxyphenyl)prop-2-yn-1-yl) oxime oxalate

InChi Key

FSSMLDVGDZVSES-XYJRJTJESA-N

InChi Code

InChI=1S/C16H18N2O2.C2H2O4/c1-19-15-6-2-4-13(10-15)5-3-9-20-17-16-12-18-8-7-14(16)11-18;3-1(4)2(5)6/h2,4,6,10,14H,7-9,11-12H2,1H3;(H,3,4)(H,5,6)/b17-16-;

SMILES Code

COC1=CC(C#CCO/N=C2CN3CCC/2C3)=CC=C1.O=C(O)C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.