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Pavinetant

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Specification

Cat. No.

SMD1612

Related Diseases

Schizophrenia

Product Name

Pavinetant

Size

1.0mg; 5.0mg; 10.0mg; 50.0mg

Price

Inquiry

Availability

2 Weeks

Description

Pavinetant, also known as MLE-4901, AZD-4901, AZ-12472520, and AZD-2624, is a small-molecule, orally active, selective neurokinin-3 (NK3) receptor antagonist which is under development by AstraZeneca and Millendo Therapeutics for the treatment of hot flashes and polycystic ovary syndrome (PCOS). It was also under investigation for the treatment of schizophrenia, but development was discontinued for this indication due to lack of effectiveness. As of 2017, the drug is in phase II clinical trials for hot flashes and PCOS.

CAS Number

941690-55-7

Chemical Formula

C26H25N3O3S

Exact Mass

459.1617

Molecular Weight

459.564

Elemental Analysis

C, 67.95; H, 5.48; N, 9.14; O, 10.44; S, 6.98

Synonym

AZD-2624; AZD2624; AZD 2624; MLE-4901; MLE4901; MLE 4901; AZD-4901; AZD 4901; AZD4901; AZ-12472520; AZ 12472520; AZ12472520; pavinetant;

IUPAC/Chemical Name

(S)-3-(methylsulfonamido)-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide

InChi Key

QYTBBBAHNIWFOD-NRFANRHFSA-N

InChi Code

InChI=1S/C26H25N3O3S/c1-3-21(18-12-6-4-7-13-18)28-26(30)23-20-16-10-11-17-22(20)27-24(19-14-8-5-9-15-19)25(23)29-33(2,31)32/h4-17,21,29H,3H2,1-2H3,(H,28,30)/t21-/m0/s1

SMILES Code

O=C(C1=C(NS(=O)(C)=O)C(C2=CC=CC=C2)=NC3=CC=CC=C13)N[C@H](C4=CC=CC=C4)CC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.