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Pardoprunox HCl

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Specification

Cat. No.

SMD371

Related Diseases

Anxiety

Product Name

Pardoprunox HCl

Size

10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; Click to view more sizes and prices

Price

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Availability

2 Weeks

Description

Pardoprunox, also known as SLV-308; DU-126891; SME-308, is dopamine D2/5-HT1A receptor agonist potentially for the treatment of Parkinson's disease. It was also being investigated for the treatment of depression and anxiety but these indications appear to have been abandoned. Pardoprunox acts as a D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist (IA = 50% and 67%, respectively) and 5-HT1A receptor (pKi = 8.5) full agonist (IA = 100%). It also binds to D4 (pKi = 7.8), α1-adrenergic (pKi = 7.8), α2-adrenergic (pKi = 7.4), and 5-HT7 receptors (pKi = 7.2) with lower affinity.

CAS Number

269718-83-4 (HCl)

Chemical Formula

C12H16ClN3O2

Molecular Weight

269.73

Elemental Analysis

C, 53.44; H, 5.98; Cl, 13.14; N, 15.58; O, 11.86

Synonym

SLV-308; SLV 308; SLV308; DU-126891; SME-308; DU126891; SME308; Pardoprunox; Pardoprunox HCl.

IUPAC/Chemical Name

7-(4-methylpiperazin-1-yl)-3H-1,3-benzoxazol-2-one hydrochloride

InChi Key

NQRIKTDKFHAOKC-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H15N3O2.ClH/c1-14-5-7-15(8-6-14)10-4-2-3-9-11(10)17-12(16)13-9;/h2-4H,5-8H2,1H3,(H,13,16);1H

SMILES Code

O=C1OC2=C(N3CCN(C)CC3)C=CC=C2N1.[H]Cl

Appearance

Pale mauve solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.