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Pardoprunox free base

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Specification

Cat. No.

SMD310

Related Diseases

Anxiety

Product Name

Pardoprunox free base

Size

1.0g; 2.0g; 5.0g

Price

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Availability

2 Weeks

Description

Pardoprunox, also known as SLV-308; DU-126891; SME-308, is dopamine D2/5-HT1A receptor agonist potentially for the treatment of Parkinson's disease. It was also being investigated for the treatment of depression and anxiety but these indications appear to have been abandoned. Pardoprunox acts as a D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist (IA = 50% and 67%, respectively) and 5-HT1A receptor (pKi = 8.5) full agonist (IA = 100%). It also binds to D4 (pKi = 7.8), α1-adrenergic (pKi = 7.8), α2-adrenergic (pKi = 7.4), and 5-HT7 receptors (pKi = 7.2) with lower affinity.

CAS Number

269718-84-5 (free base)

Chemical Formula

C12H15N3O2

Exact Mass

233.1164

Molecular Weight

233.271

Elemental Analysis

C, 61.79; H, 6.48; N, 18.01; O, 13.72

Synonym

SLV-308; SLV 308; SLV308; DU-126891; SME-308; DU126891; SME308; Pardoprunox; Pardoprunox

IUPAC/Chemical Name

7-(4-methylpiperazin-1-yl)-3H-1,3-benzoxazol-2-one

InChi Key

YVPUUUDAZYFFQT-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H15N3O2/c1-14-5-7-15(8-6-14)10-4-2-3-9-11(10)17-12(16)13-9/h2-4H,5-8H2,1H3,(H,13,16)

SMILES Code

O=C1OC2=C(N3CCN(C)CC3)C=CC=C2N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.