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Paraxanthine-d6

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Specification

Cat. No.

SMD328

Related Diseases

Anxiety

Product Name

Paraxanthine-d6

Size

1.0mg; 5.0mg

Price

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Availability

2 Weeks

Description

Paraxanthine-d6 is intended for use as an internal standard for the quantification of paraxanthine by GC- or LC-MS. Paraxanthine is an active metabolite of caffeine. It is formed via N3-demethylation of caffeine by the cytochrome P450 (CYP) isoform CYP1A2. Paraxanthine is an adenosine A1 and A2 receptor antagonist. In vivo, paraxanthine increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by the adenosine A1 agonist CPA or the adenosine A2 receptor agonist CGS 21680 in rats not habituated to caffeine. It also promotes wakefulness and increases locomotor activity and core temperature in narcoleptic transgenic mice without increasing behavioral anxiety.

CAS Number

117490-41-2

Chemical Formula

C7H2D6N4O2

Exact Mass

186.1024

Molecular Weight

186.2036

Elemental Analysis

C, 45.15; H, 7.57; N, 30.09; O, 17.18

Synonym

Paraxanthine-d6; 1,7-Dimethylxanthine-d6;

IUPAC/Chemical Name

1,7-bis(methyl-d3)-3,7-dihydro-1H-purine-2,6-dione

InChi Key

QUNWUDVFRNGTCO-WFGJKAKNSA-N

InChi Code

InChI=1S/C7H8N4O2/c1-10-3-8-5-4(10)6(12)11(2)7(13)9-5/h3H,1-2H3,(H,9,13)/i1D3,2D3

SMILES Code

O=C1C2=C(NC(N1C([2H])([2H])[2H])=O)N=CN2C([2H])([2H])[2H]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.